Abstract |
Myogenin immunostaining has been described as a useful marker of the alveolar subtype of rhabdomyosarcoma and as a tool for distinguishing it from the more common embryonal subtype. To add to the growing body of literature describing this phenomenon we analysed myogenin immunohistochemical staining in 152 tumors using a rhabdomyosarcoma tissue array. Results were analysed blinded to histological type by two independent investigators. Samples were excluded if any samples failed to stain with desmin and/or myogenin. Mean percentage of myogenin positive cells was significantly greater for ARMS (n = 31; mean percentage positivity 59% (95% confidence intervals +/- 7%) than ERMS (n = 41, mean percentage positivity 16%, 95% confidence intervals +/- 4; P < 0.0001). This data is consistent with previously published studies identifying strong nuclear myogenin staining in a high proportion of cells as a marker of alveolar histology.
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Authors | D A Morgenstern, H Rees, N J Sebire, J Shipley, John Anderson |
Journal | Pathology oncology research : POR
(Pathol Oncol Res)
Vol. 14
Issue 3
Pg. 233-8
(Sep 2008)
ISSN: 1219-4956 [Print] Switzerland |
PMID | 18493875
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
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Chemical References |
- Biomarkers, Tumor
- Myogenin
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Topics |
- Biomarkers, Tumor
(metabolism)
- Diagnosis, Differential
- Humans
- Myogenin
(metabolism)
- Prognosis
- Rhabdomyosarcoma, Alveolar
(classification, diagnosis, metabolism)
- Rhabdomyosarcoma, Embryonal
(classification, diagnosis, metabolism)
- Sensitivity and Specificity
- Tissue Array Analysis
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