Abstract | RATIONALE: OBJECTIVES: The aim of the current study was to investigate the cognition enhancing properties of ciproxifan, an H3 receptor antagonist, after natural forgetting in normal adult rats. MATERIALS AND METHODS: The novel object discrimination task, a recognition memory test based on spontaneous exploratory behaviour, was used. Briefly, rats exposed to two identical objects during an acquisition trial can discriminate between a novel object and a familiar one during a subsequent choice trial after a short delay but not after a 24-h inter-trial interval. RESULTS: The scopolamine (0.5 mg/kg, i.p.)-induced impairment after a short delay was abolished by ciproxifan (p < 0.001). Natural forgetting was prevented by a single administration of ciproxifan (3 mg/kg) prior to the retention test (p < 0.001) but not when administered before or immediately after the acquisition trial (schedule effect p < 0.05), demonstrating a specific activity on memory retrieval. Pretreatment with either pyrilamine (10 mg/kg), an H1 antagonist, or zolantidine (10 mg/kg), an H2 antagonist, prevented the retrieval enhancement effect of ciproxifan (p < 0.05 and p < 0.001, respectively). CONCLUSIONS:
Histamine H3 receptor antagonists restore the performance of rats impaired by scopolamine and enhance recognition memory after acute administration before the retrieval phase via a mechanism dependent on H1 and H2 receptor activation.
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Authors | Vincent Pascoli, Corinne Boer-Saccomani, Jean-François Hermant |
Journal | Psychopharmacology
(Psychopharmacology (Berl))
Vol. 202
Issue 1-3
Pg. 141-52
(Jan 2009)
ISSN: 1432-2072 [Electronic] Germany |
PMID | 18493749
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Histamine H1 Antagonists
- Histamine H2 Antagonists
- Histamine H3 Antagonists
- Imidazoles
- Muscarinic Antagonists
- Piperidines
- ciproxifan
- Scopolamine
- thioperamide
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Topics |
- Animals
- Discrimination Learning
(drug effects)
- Discrimination, Psychological
(drug effects)
- Exploratory Behavior
(drug effects)
- Histamine H1 Antagonists
(pharmacology)
- Histamine H2 Antagonists
(pharmacology)
- Histamine H3 Antagonists
(pharmacology)
- Histamine Release
(drug effects)
- Imidazoles
(pharmacology)
- Male
- Memory
(drug effects)
- Mental Recall
(drug effects)
- Muscarinic Antagonists
(pharmacology)
- Piperidines
(pharmacology)
- Psychomotor Performance
(drug effects)
- Rats
- Rats, Wistar
- Recognition, Psychology
(drug effects)
- Scopolamine
(antagonists & inhibitors, pharmacology)
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