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Prolonged remission of severe Cushing syndrome without adrenalectomy in an infant with McCune-Albright syndrome.

Abstract
A 4 month-old girl presented with severe Cushing syndrome caused by McCune-Albright syndrome. After undergoing 19 months of pharmacologic suppression of cortisol production, she has been in clinical remission for more than 6 years. Adrenalectomy may be avoidable even in severe cases of Cushing syndrome associated with McCune-Albright syndrome.
AuthorsDavid Gillis, Ariel Rösler, Tamara S Hannon, Benjamin Z Koplewitz, Harry J Hirsch
JournalThe Journal of pediatrics (J Pediatr) Vol. 152 Issue 6 Pg. 882-4, 884.e1-4 (Jun 2008) ISSN: 1097-6833 [Electronic] United States
PMID18492536 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Adrenergic Agents
  • Enzyme Inhibitors
  • Aminoglutethimide
  • Metyrapone
Topics
  • Adrenalectomy
  • Adrenergic Agents (therapeutic use)
  • Aminoglutethimide (therapeutic use)
  • Child
  • Cushing Syndrome (drug therapy, etiology)
  • Enzyme Inhibitors (therapeutic use)
  • Female
  • Fibrous Dysplasia, Polyostotic (complications)
  • Follow-Up Studies
  • Humans
  • Infant
  • Metyrapone (therapeutic use)
  • Remission Induction
  • Severity of Illness Index
  • Time Factors

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