Abstract | BACKGROUND: OBJECTIVE: METHODS: First, the potential mechanism, pharmacokinetics and metabolism of mecobalamin were clarified. In addition, the clinical administration including efficacy, safety and tolerability of mecobalamin as monotherapy or combined therapy in the treatment of hyperhomocysteinaemia and peripheral neuropathy were also detailed. RESULTS/CONCLUSIONS: Although both monotherapy and combined therapy can lower plasma/serum homocysteine levels and improve the neuropathic symptoms, combined therapy with other B vitamins seems to be more effective. However, more precise, double-blind and randomised control studies are necessary to confirm the efficacy of mecobalamin on hyperhomocysteinaemia, peripheral neuropathy interaction, and cardiovascular, neurological and osteoporotic mortality or morbidity.
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Authors | Yi-Fei Zhang, Guang Ning |
Journal | Expert opinion on investigational drugs
(Expert Opin Investig Drugs)
Vol. 17
Issue 6
Pg. 953-64
(Jun 2008)
ISSN: 1744-7658 [Electronic] England |
PMID | 18491996
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
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Chemical References |
- Cobamides
- Coenzymes
- Hypoglycemic Agents
- Vitamin B 6
- Metformin
- Folic Acid
- Methionine
- mecobalamin
- Methyltransferases
- Alprostadil
- Vitamin B 12
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Topics |
- Aged
- Alprostadil
(administration & dosage, therapeutic use)
- Animals
- Cobamides
(physiology)
- Coenzymes
(physiology)
- Diabetic Neuropathies
(drug therapy, prevention & control)
- Drug Administration Routes
- Drug Therapy, Combination
- Female
- Folic Acid
(administration & dosage, therapeutic use)
- Humans
- Hyperhomocysteinemia
(complications, drug therapy)
- Hypoglycemic Agents
(adverse effects)
- Kidney Failure, Chronic
(drug therapy, therapy)
- Male
- Metformin
(adverse effects)
- Methionine
(metabolism)
- Methyltransferases
(metabolism)
- Peripheral Nervous System Diseases
(drug therapy)
- Randomized Controlled Trials as Topic
(statistics & numerical data)
- Renal Dialysis
(adverse effects)
- Vitamin B 12
(administration & dosage, analogs & derivatives, chemistry, pharmacology, therapeutic use)
- Vitamin B 12 Deficiency
(chemically induced, complications, drug therapy)
- Vitamin B 6
(administration & dosage, therapeutic use)
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