HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Mecobalamin.

AbstractBACKGROUND:
Mecobalamin, one of the coenzyme forms of vitamin B(12), acts as an important cofactor in the activities of B(12)-dependent methyltransferases. Since the discovery of mecobalamin, it has been applied mainly in the treatment of hyperhomocysteinaemia and peripheral neuropathy. However, there is still lack of a systemic review on the clinical administration of mecobalamin and its potential mechanism.
OBJECTIVE:
To review the mechanism, clinical efficacy and safety of mecobalamin in the treatment of hyperhomocysteinaemia and peripheral neuropathy.
METHODS:
First, the potential mechanism, pharmacokinetics and metabolism of mecobalamin were clarified. In addition, the clinical administration including efficacy, safety and tolerability of mecobalamin as monotherapy or combined therapy in the treatment of hyperhomocysteinaemia and peripheral neuropathy were also detailed.
RESULTS/CONCLUSIONS:
Although both monotherapy and combined therapy can lower plasma/serum homocysteine levels and improve the neuropathic symptoms, combined therapy with other B vitamins seems to be more effective. However, more precise, double-blind and randomised control studies are necessary to confirm the efficacy of mecobalamin on hyperhomocysteinaemia, peripheral neuropathy interaction, and cardiovascular, neurological and osteoporotic mortality or morbidity.
AuthorsYi-Fei Zhang, Guang Ning
JournalExpert opinion on investigational drugs (Expert Opin Investig Drugs) Vol. 17 Issue 6 Pg. 953-64 (Jun 2008) ISSN: 1744-7658 [Electronic] England
PMID18491996 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
Chemical References
  • Cobamides
  • Coenzymes
  • Hypoglycemic Agents
  • Vitamin B 6
  • Metformin
  • Folic Acid
  • Methionine
  • mecobalamin
  • Methyltransferases
  • Alprostadil
  • Vitamin B 12
Topics
  • Aged
  • Alprostadil (administration & dosage, therapeutic use)
  • Animals
  • Cobamides (physiology)
  • Coenzymes (physiology)
  • Diabetic Neuropathies (drug therapy, prevention & control)
  • Drug Administration Routes
  • Drug Therapy, Combination
  • Female
  • Folic Acid (administration & dosage, therapeutic use)
  • Humans
  • Hyperhomocysteinemia (complications, drug therapy)
  • Hypoglycemic Agents (adverse effects)
  • Kidney Failure, Chronic (drug therapy, therapy)
  • Male
  • Metformin (adverse effects)
  • Methionine (metabolism)
  • Methyltransferases (metabolism)
  • Peripheral Nervous System Diseases (drug therapy)
  • Randomized Controlled Trials as Topic (statistics & numerical data)
  • Renal Dialysis (adverse effects)
  • Vitamin B 12 (administration & dosage, analogs & derivatives, chemistry, pharmacology, therapeutic use)
  • Vitamin B 12 Deficiency (chemically induced, complications, drug therapy)
  • Vitamin B 6 (administration & dosage, therapeutic use)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: