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Granular parakeratosis in a patient treated with liposomal doxorubicin for ovarian carcinoma.

Abstract
Granular parakeratosis is a rare benign dermatosis caused by an acquired disorder of keratinization that usually manifests with reddish-brown keratotic papules and plaques in intertriginous areas. It has specific histologic features but its pathogenesis remains unclear. Its frequency is probably underestimated because the condition is usually misdiagnosed as simple intertrigo. We report herein a new case of granular parakeratosis in a woman treated with liposomal doxorubicin for ovarian carcinoma that showed complete remission after discontinuation of chemotherapy. The relationship between granular parakeratosis and chemotherapy is discussed.
AuthorsLaure Jaconelli, Bénédicte Doebelin, Jean Kanitakis, Benoît Ben Saïd, Michel Faure, Alain Claudy
JournalJournal of the American Academy of Dermatology (J Am Acad Dermatol) Vol. 58 Issue 5 Suppl 1 Pg. S84-7 (May 2008) ISSN: 1097-6787 [Electronic] United States
PMID18489055 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Antibiotics, Antineoplastic
  • liposomal doxorubicin
  • Polyethylene Glycols
  • Doxorubicin
Topics
  • Antibiotics, Antineoplastic (adverse effects)
  • Doxorubicin (adverse effects, analogs & derivatives)
  • Epidermis (pathology)
  • Female
  • Humans
  • Middle Aged
  • Ovarian Neoplasms (drug therapy)
  • Parakeratosis (chemically induced, pathology)
  • Polyethylene Glycols (adverse effects)

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