Abstract | OBJECTIVE: RESEARCH DESIGN AND METHODS: Four single nucleotide polymorphisms within SLC2A9 (rs6855911, rs7442295, rs6449213, and rs12510549) were genotyped in the population-based prospective Bruneck Study (n = 800) and in a case-control study from Utah including 1,038 subjects recruited for severe obesity and 831 control subjects. RESULTS: We observed highly significant associations between all four polymorphisms and uric acid levels in all study groups. Each copy of the minor allele decreased age- and sex-adjusted uric acid levels by 0.30-0.35 mg/dl on average, which translates to a relative decrease of 5-6% with P values ranging from 10(-9) to 10(-11) in the combined analysis. An extended adjustment for BMI, creatinine, gout medication, and alcohol intake improved P values to a range of 10(-14) to 10(-20). The association was more pronounced in women and the population-based Bruneck Study and was significantly modified by BMI, with stronger effect sizes in individuals with high BMI. CONCLUSIONS: Genetic variants within SLC2A9 have significant effects on uric acid levels and are modified by sex and BMI.
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Authors | Anita Brandstätter, Stefan Kiechl, Barbara Kollerits, Steven C Hunt, Iris M Heid, Stefan Coassin, Johann Willeit, Ted D Adams, Thomas Illig, Paul N Hopkins, Florian Kronenberg |
Journal | Diabetes care
(Diabetes Care)
Vol. 31
Issue 8
Pg. 1662-7
(Aug 2008)
ISSN: 1935-5548 [Electronic] United States |
PMID | 18487473
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Chemical References |
- Glucose Transport Proteins, Facilitative
- SLC2A9 protein, human
- Uric Acid
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Topics |
- Adult
- Aged
- Austria
- Body Mass Index
- Diabetes Mellitus, Type 2
(genetics)
- Female
- Genetic Variation
- Genotype
- Glucose Transport Proteins, Facilitative
(genetics)
- Humans
- Male
- Middle Aged
- Obesity
(genetics)
- Polymorphism, Single Nucleotide
- Reference Values
- Sex Characteristics
- Uric Acid
(blood)
- Utah
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