Clinical effects of torasemide prolonged release in mild-to-moderate hypertension: a randomized noninferiority trial versus torasemide immediate release.

Abstract	The efficacy of a new torasemide prolonged release (PR) formulation to torasemide immediate release (IR) was compared in a randomized noninferiority double-blind trial. Patients with newly diagnosed mild-to-moderate hypertension or unresponsive or poor tolerability to previous antihypertensive monotherapy received 5 mg/day of torasemide-PR (n = 219) or torasemide-IR (n = 223) for 12 weeks (uptitration to 10 mg/day if no response at 4 or 8 weeks). Mean diastolic blood pressure (DBP) reduction in the torasemide-PR group (11.6 +/- 7.1 mmHg, 95% confidence interval [CI] 10.6-12.5) versus torasemide-IR (11.3 +/- 7.5 mmHg, 95% CI 10.2-12.3) met the noninferiority criterion of a nonsided 97.5% CI lower than the preestablished margin of 2 mmHg. A significantly higher percentage of patients in the torasemide-PR group achieved adequate BP control after 8 and 12 weeks. Ambulatory 24-h BP monitoring (ABPM) measurements in a subset of 100 patients showed greater daytime SBP reductions in the torasemide-PR group (128.4 +/- 9.9 mmHg vs. 133.5 +/- 10.4 mmHg, P < 0.05). Safety and tolerability of both formulations were similar.
Authors	Alex Roca-Cusachs, Joaquín Aracil-Vilar, Carlos Calvo-Gómez, José-Vicente Vaquer-Pérez, Félix Laporta-Crespo, María-José Rojas-Serrano, Antonio Guglietta, Savion Gropper, Torasemide-PR in Hypertension Clinical Trial Investigators Group
Journal	Cardiovascular therapeutics (Cardiovasc Ther) Vol. 26 Issue 2 Pg. 91-100 ( 2008) ISSN: 1755-5914 [Print] England
PMID	18485132 (Publication Type: Comparative Study, Journal Article, Multicenter Study, Randomized Controlled Trial)
Chemical References	Antihypertensive Agents Delayed-Action Preparations Diuretics Sulfonamides Torsemide
Topics	Adult Aged Antihypertensive Agents (adverse effects, therapeutic use) Blood Pressure (drug effects) Blood Pressure Monitoring, Ambulatory Delayed-Action Preparations Diuretics (adverse effects, therapeutic use) Double-Blind Method Female Humans Hypertension (drug therapy, physiopathology) Male Middle Aged Severity of Illness Index Spain Sulfonamides (adverse effects, therapeutic use) Time Factors Torsemide Treatment Outcome Urination (drug effects)

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