Abstract | BACKGROUND: Inhaled glucocorticosteroids are usually administered in two equal daily doses. To simplify the method of treatment, once-daily administration has been used. However, little information regarding whether once-daily treatment can sufficiently control airway inflammation is available. We aimed to investigate whether once-daily administration of inhaled glucocorticosteroids can control airway inflammation. METHODS: Twenty-four well-controlled asthma patients were enrolled in a randomized crossover trial to compare the efficacies of once-daily and twice-daily administration of inhaled glucocorticosteroids. Initially, the patients were randomly assigned to receive either once-daily or twice-daily administration for 16 weeks. After an 8-week washout period, patients who originally received twice-daily administration were assigned to once-daily administration for 16 weeks and vice versa. We assessed the changes in the forced expiratory volume in 1s, morning and evening peak expiratory flows, asthma symptoms, health-related quality of life and fractional exhaled nitric oxide levels. RESULTS: Patients with once-daily administration showed the same level of clinical control and lung functions as patients receiving twice-daily administration. There was no difference in the fractional exhaled nitric oxide levels between the beginning and end of the twice-daily treatment (35.69 and 33.23ppb, respectively). In contrast, the fractional exhaled nitric oxide level was significantly higher at the end of the once-daily treatment (33.87 and 39.38ppb, respectively, p< 0.001). CONCLUSION:
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Authors | Hirotsugu Hasegawa, Naoki Inui, Tomoyuki Fujisawa, Jun Sato, Hirotoshi Nakamura, Hiroshi Watanabe, Takafumi Suda, Kingo Chida |
Journal | Pulmonary pharmacology & therapeutics
(Pulm Pharmacol Ther)
Vol. 21
Issue 4
Pg. 663-7
(Aug 2008)
ISSN: 1094-5539 [Print] England |
PMID | 18479954
(Publication Type: Journal Article, Randomized Controlled Trial)
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Chemical References |
- Glucocorticoids
- Nitric Oxide
- Budesonide
- Beclomethasone
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Topics |
- Administration, Inhalation
- Adult
- Aged
- Asthma
(drug therapy)
- Beclomethasone
(administration & dosage, therapeutic use)
- Breath Tests
- Budesonide
(administration & dosage, therapeutic use)
- Cross-Over Studies
- Drug Administration Schedule
- Female
- Forced Expiratory Volume
(drug effects)
- Glucocorticoids
(administration & dosage, therapeutic use)
- Humans
- Male
- Middle Aged
- Nitric Oxide
(metabolism)
- Quality of Life
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