Abstract | INTRODUCTION: Animal models of thrombosis and hemostasis are critical for target validation in pharmaceutical research. Guinea pig haemostatic mechanisms, such as the platelet thrombin receptor repertoire, resemble those of humans. Measuring the performance characteristics of marketed antithrombotic drugs in guinea pig models is a key to predicting therapeutic indices of new agents. The goal of the current study was to benchmark representative marketed drugs in thrombosis and hemostasis models in guinea pigs. METHODS: RESULTS: CONCLUSION: This characterization of representative drugs from two important classes of anti- coagulant and anti-platelet agents in efficacy and bleeding models in guinea pigs provides a reference point for evaluation of new antithrombotic agents.
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Authors | J Eileen Bird, Mary R Giancarli, Nick Allegretto, Frank Barbera, Pancras Wong, William A Schumacher, Martin L Ogletree, Dietmar Seiffert |
Journal | Thrombosis research
(Thromb Res)
Vol. 123
Issue 1
Pg. 146-58
( 2008)
ISSN: 0049-3848 [Print] United States |
PMID | 18479740
(Publication Type: Journal Article)
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Chemical References |
- Anticoagulants
- Chlorides
- Ferric Compounds
- Pipecolic Acids
- Platelet Aggregation Inhibitors
- Sulfonamides
- Tyrosine
- Arginine
- Tirofiban
- argatroban
- Aspirin
- ferric chloride
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Topics |
- Animals
- Anticoagulants
(therapeutic use)
- Arginine
(analogs & derivatives)
- Arteriovenous Shunt, Surgical
(adverse effects)
- Aspirin
(therapeutic use)
- Bleeding Time
- Chlorides
- Ferric Compounds
(pharmacology)
- Guinea Pigs
- Hemostasis
(drug effects)
- Male
- Pipecolic Acids
(therapeutic use)
- Platelet Aggregation Inhibitors
(therapeutic use)
- Sulfonamides
- Thrombosis
(drug therapy)
- Tirofiban
- Tyrosine
(analogs & derivatives, therapeutic use)
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