Abstract | OBJECTIVE: METHODS: Twelve patients presenting with cancers of the head and neck region with Radiation Therapy Oncology Group (RTOG) grade 2 or more skin toxicity were offered topical treatment of silver sulfadiazine and silver leaf dressing. Each patient applied silver-leaf dressing on one side of the neck and silver sulfadiazine on the other. Three independent observers evaluated the patients based on standardized digital photography and regular follow-up by the treating physician. The sign test was used to evaluate whether the observed difference was statistically significant. RESULTS: There was no improvement in RTOG grade skin toxicity. However, within the same grade, two of three observers agreed on some degree of improvement in the dermatitis with silver leaf dressing compared with silver sulfadiazine. As well, 67% of patients reported improved pain control on the side treated with silver leaf dressing. Sign test analysis indicated that the use of silver-leaf dressing gave significantly superior results when compared with silver sulfadiazine (p = .035). CONCLUSION:
Silver leaf dressing does not appear to be superior to our standard treatment for radiation-induced dermatitis when the RTOG grading system is used. It does, however, seem to reduce the severity of reaction within the same grade, accelerate healing, and provide improved pain control over standard treatment. It shows promise regarding symptom control and merits further investigation.
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Authors | Peter Vavassis, Michel Gelinas, Jean Chabot Tr, Phuc Felix Nguyen-Tân |
Journal | Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale
(J Otolaryngol Head Neck Surg)
Vol. 37
Issue 1
Pg. 124-9
(Feb 2008)
ISSN: 1916-0216 [Electronic] England |
PMID | 18479639
(Publication Type: Clinical Trial, Phase II, Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anti-Infective Agents, Local
- Silver
- Silver Sulfadiazine
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Topics |
- Anti-Infective Agents, Local
(administration & dosage)
- Bandages
- Carcinoma, Squamous Cell
(radiotherapy)
- Head and Neck Neoplasms
(radiotherapy)
- Humans
- Radiodermatitis
(drug therapy)
- Silver
(administration & dosage)
- Silver Sulfadiazine
(administration & dosage)
- Wound Healing
(drug effects)
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