The reactions of tetraethylthiouram
disulfide (DTS), an inhibitor of the nephrotoxicity of Pt(II) drugs, an efficient agent in the treatment of chronic
alcoholism, in the treatment of
HIV infections,
AIDS and
heavy metal toxicity, and a fungicide and
herbicide, with K(2)[PtCl(4)], in ratio 1:1 and 1:2, gave the compounds [PtCl(2)DTS] and [Pt(S(2)CNEt(2))(2)] respectively. The reaction of the complexes K(2)[
PdCl(4)], Pd(AcO)(2) and [
PdCl(2)(PhCN)(2)], where PhCN =
Benzonitrile, with tetraethylthiouram
disulfide in ratio 1:1 or 1:2, yielded orange crystals identified as [Pd(S(2)CNEt(2))(2)]. The crystals were suitable for study by X-ray diffraction. The -S-S- bridge in the tetraethylthiouram disulfude molecule was broken and the two molecules of the
thiocarbamate derivative were bound to the Pd(II) by the equivalents
sulfur atoms. All the compounds were characterized by IR, (1)H and (13)C NMR spectroscopies.