Role of hyperglycemia in isogeneic islet transplantation: an experimental animal study.

Abstract

OBJECTIVE:

Study the role of hyperglycemia-induced beta cell loss on grafted islet destruction.

DESIGN:

Male inbred rats were made diabetic by streptozotocin administration and used as islet donors and/or isograft recipients to probe directly the role of hyperglycemia as an important determinant of transplanted islet fate, following exclusion of immune-related causes of islet graft destruction like allograft immunity and disease recurrence.

RESULTS:

Our studies showed that: a) Hyperglycemia destroyed islet but not pituitary isografts and b) Tight control of normoglycemia by sufficient islet mass engraftment prevented graft damage.

CONCLUSION:

While sustained hyperglycemia caused destruction of transplanted islet isografts, induction of normoglycemia by transplantation of sufficient islet mass to diabetic recipients had a beneficial long term effect on their functional engraftment.

• Authors: I Nomikos, K Kalogerakos, E Athanasiou, E Plakokefalos, E Plakokefales, D Sioutopoulou, M Satra, N C Vamvakopoulos
• Journal: Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association (Exp Clin Endocrinol Diabetes) Vol. 116 Issue 9 Pg. 558-60 (Oct 2008) ISSN: 0947-7349 [Print] Germany
• PMID: 18473285 (Publication Type: Journal Article)

Topics

• Animals
• Diabetes Mellitus, Experimental (surgery)
• Hyperglycemia (pathology, physiopathology)
• Islets of Langerhans Transplantation (pathology)
• Male
• Rats
• Rats, Inbred Lew
• Rats, Inbred Strains
• Transplantation, Isogeneic