Abstract | BACKGROUND AND PURPOSE:
Cannabidiol is a Cannabis-derived non-psychotropic compound that exerts a plethora of pharmacological actions, including anti-inflammatory, neuroprotective and antitumour effects, with potential therapeutic interest. However, the actions of cannabidiol in the digestive tract are largely unexplored. In the present study, we investigated the effect of cannabidiol on intestinal motility in normal (control) mice and in mice with intestinal inflammation. EXPERIMENTAL APPROACH: Motility in vivo was measured by evaluating the distribution of an orally administered fluorescent marker along the small intestine; intestinal inflammation was induced by the irritant croton oil; contractility in vitro was evaluated by stimulating the isolated ileum, in an organ bath, with ACh. KEY RESULTS: CONCLUSIONS AND IMPLICATIONS:
|
Authors | R Capasso, F Borrelli, G Aviello, B Romano, C Scalisi, F Capasso, A A Izzo |
Journal | British journal of pharmacology
(Br J Pharmacol)
Vol. 154
Issue 5
Pg. 1001-8
(Jul 2008)
ISSN: 0007-1188 [Print] England |
PMID | 18469842
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Cholinergic Agents
- Enzyme Inhibitors
- Gastrointestinal Agents
- Piperidines
- Pyrazoles
- Receptor, Cannabinoid, CB1
- Cannabidiol
- Loperamide
- Croton Oil
- Amidohydrolases
- fatty-acid amide hydrolase
- Acetylcholine
- Rimonabant
|
Topics |
- Acetylcholine
(pharmacology)
- Amidohydrolases
(antagonists & inhibitors, metabolism)
- Animals
- Cannabidiol
(pharmacology)
- Cannabis
(chemistry)
- Cholinergic Agents
(pharmacology)
- Croton Oil
- Disease Models, Animal
- Dose-Response Relationship, Drug
- Enzyme Inhibitors
(pharmacology)
- Gastrointestinal Agents
(pharmacology)
- Gastrointestinal Motility
(drug effects)
- Gastrointestinal Transit
(drug effects)
- Ileitis
(chemically induced, drug therapy, physiopathology)
- Ileum
(drug effects, metabolism, physiopathology)
- Loperamide
(pharmacology)
- Male
- Mice
- Mice, Inbred ICR
- Piperidines
(pharmacology)
- Pyrazoles
(pharmacology)
- Receptor, Cannabinoid, CB1
(drug effects)
- Rimonabant
|