Abstract | OBJECTIVES: To assess whether prolotherapy, an injection-based therapy, improves elbow pain, grip strength, and extension strength in patients with lateral epicondylosis. SETTING: Outpatient Sport Medicine clinic. STUDY DESIGN: Double-blind randomized controlled trial. PARTICIPANTS: Twenty-four adults with at least 6 months of refractory lateral epicondylosis. INTERVENTION: OUTCOME MEASURES: The primary outcome was resting elbow pain (0 to 10 Likert scale). Secondary outcomes were extension and grip strength. Each was performed at baseline and at 8 and 16 weeks. One-year follow-up included pain assessment and effect of pain on activities of daily living. RESULTS: : The groups were similar at baseline. Compared to Controls, Prolotherapy subjects reported improved pain scores (4.5 +/- 1.7, 3.6 +/- 1.2, and 3.5 +/- 1.5 versus 5.1 +/- 0.8, 3.3 +/- 0.9, and 0.5 +/- 0.4 at baseline and at 8 and 16 weeks, respectively). At 16 weeks, these differences were significant compared to baseline scores within and among groups (P < 0.001). Prolotherapy subjects also reported improved extension strength compared to Controls (P < 0.01) and improved grip strength compared to baseline (P < 0.05). Clinical improvement in Prolotherapy group subjects was maintained at 52 weeks. There were no adverse events. CONCLUSIONS:
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Authors | Michael Scarpone, David P Rabago, Aleksandra Zgierska, Gennie Arbogast, Edward Snell |
Journal | Clinical journal of sport medicine : official journal of the Canadian Academy of Sport Medicine
(Clin J Sport Med)
Vol. 18
Issue 3
Pg. 248-54
(May 2008)
ISSN: 1050-642X [Print] United States |
PMID | 18469566
(Publication Type: Journal Article, Randomized Controlled Trial)
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Chemical References |
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Topics |
- Adolescent
- Adult
- Double-Blind Method
- Drug Combinations
- Female
- Humans
- Injections
- Male
- Middle Aged
- Ohio
- Pilot Projects
- Tennis Elbow
(drug therapy, physiopathology)
- Treatment Outcome
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