Vagus nerve stimulation for intractable epilepsy in tuberous sclerosis complex.

Abstract

OBJECTIVES:

The aim of the study described here was to characterize the efficacy and safety of vagus nerve stimulation in a population of patients with tuberous sclerosis complex (TSC) and intractable epilepsy.

METHODS:

This retrospective study comprised 16 patients with TSC who underwent implantation of a vagus nerve stimulator for treatment of intractable epilepsy.

RESULTS:

The average age at vagus nerve stimulator implantation was 15 years (range: 2-44, SD: 12.5) and the average duration of follow-up on VNS was 4 years (range: 0.5-8.6, SD: 2.3). Outcome was rated class I (>80% seizure frequency reduction) in 3 (19%), class II (50-79% reduction) in 5 (31%), class III (<50% reduction) in 2 (13%), class IV (magnet benefit only) in 1 (6%), and class V (no improvement) in 5 (31%) patients. Intermittent magnet use was effective in aborting seizures in 8 (50%). Five (31%) patients reported an improved level of functioning.

CONCLUSION:

The findings suggest that the vagus nerve stimulation can be an effective and safe therapy for patients with TSC with intractable epilepsy.

• Authors: Philippe Major, Elizabeth A Thiele
• Journal: Epilepsy & behavior : E&B (Epilepsy Behav) Vol. 13 Issue 2 Pg. 357-60 (Aug 2008) ISSN: 1525-5069 [Electronic] United States
• PMID: 18468492 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Topics

• Adolescent
• Adult
• Child
• Child, Preschool
• Electric Stimulation Therapy (instrumentation)
• Electroencephalography
• Epilepsy (etiology, physiopathology, therapy)
• Female
• Humans
• Male
• Prostheses and Implants
• Retrospective Studies
• Treatment Outcome
• Tuberous Sclerosis (complications, physiopathology, therapy)
• Vagus Nerve (physiopathology)