Efficacy of Nyoshinsan/TJ-67, a traditional herbal medicine, for menopausal symtoms following surgery and adjuvant chemotherapy for premenopausal breast cancer.

Abstract	We report a 39-year-old woman with premenopausal breast cancer who developed estrogen-deficiency symptoms associated with chemotherapy-related amenorrhea, and was successfully treated with Nyoshinsan/TJ-67, a Japanese traditional herbal medicine (Kampo). Six other breast cancer survivors with menopausal symptoms were also treated with Nyoshinsan/TJ-67, and five of the six patients showed noticeable improvement without adverse effects. Managing estrogen-deficiency symptoms in breast cancer survivors is still problematic, and Nyoshinsan/TJ-67 may be a useful and safe agent for such symptoms in these patients.
Authors	Toshiaki Kogure, Katsuhiko Ito, Hiroko Sato, Tomoyuki Ito, Yuko Oku, Jun Horiguchi, Izumi Takeyoshi, Takeshi Tatsumi
Journal	International journal of clinical oncology (Int J Clin Oncol) Vol. 13 Issue 2 Pg. 185-9 (Apr 2008) ISSN: 1341-9625 [Print] Japan
PMID	18463968 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Antineoplastic Agents Estrogens Plant Extracts nyoshinsan
Topics	Adult Antineoplastic Agents (adverse effects) Breast Neoplasms (drug therapy) Chemotherapy, Adjuvant (adverse effects) Estrogens (deficiency) Female Herbal Medicine Humans Middle Aged Plant Extracts (therapeutic use) Premenopause

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