Abstract | RATIONALE: OBJECTIVE: MATERIALS AND METHODS: RESULTS: In C57BL/6J mice, ketamine, phencyclidine (PCP), and dizocilpine (MK-801) all enhanced GHB-induced catalepsy. They did so with a potency order (i.e., MK-801 > PCP > ketamine) consistent with their relative potencies as NMDA antagonists but not as inhibitors of dopamine or organic cation transporters. Ketamine, PCP, and MK-801 enhanced catalepsy along inverted U-shaped dose-response curves likely because higher doses affected motor coordination, which limited their catalepsy-enhancing effects. Doses that were maximally effective to enhance GHB-induced catalepsy did not affect the cataleptic effects of baclofen. CONCLUSIONS:
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Authors | Wouter Koek, Charles P France |
Journal | Psychopharmacology
(Psychopharmacology (Berl))
Vol. 199
Issue 2
Pg. 191-8
(Aug 2008)
ISSN: 0033-3158 [Print] Germany |
PMID | 18446324
(Publication Type: Journal Article, Research Support, N.I.H., Extramural)
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Chemical References |
- Anesthetics, Intravenous
- Excitatory Amino Acid Antagonists
- Muscle Relaxants, Central
- Receptors, GABA-B
- Receptors, N-Methyl-D-Aspartate
- Ketamine
- Dizocilpine Maleate
- Sodium Oxybate
- Baclofen
- Phencyclidine
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Topics |
- Anesthetics, Intravenous
(pharmacology)
- Animals
- Area Under Curve
- Ataxia
(chemically induced, psychology)
- Baclofen
(pharmacology)
- Catalepsy
(chemically induced)
- Data Interpretation, Statistical
- Dizocilpine Maleate
(pharmacology)
- Dose-Response Relationship, Drug
- Excitatory Amino Acid Antagonists
(pharmacology)
- Ketamine
(pharmacology)
- Male
- Mice
- Mice, Inbred C57BL
- Muscle Relaxants, Central
(pharmacology)
- Phencyclidine
(pharmacology)
- Receptors, GABA-B
(drug effects)
- Receptors, N-Methyl-D-Aspartate
(antagonists & inhibitors)
- Sodium Oxybate
(pharmacology)
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