Abstract | AIMS: METHODS: Thirty-one diabetic HNF-1alpha MODY patients (mean age 37.2 +/- 14.6 years) and 35 healthy control subjects (39.1 +/- 13.9 years) participated. In addition, 25 Type 1 diabetic (T1DM) subjects were also examined (mean age 30.6 +/- 10.1 years). Exocrine pancreas function was assessed by measurement of stool elastase 1 (E1) activity. All diabetic patients and control subjects completed a gastrointestinal (GI) symptoms questionnaire. RESULTS: In all but two individuals, stool E1 levels were normal (> 200 microg/g). The only case of severely impaired pancreas exocrine function (E1 = 47.5 microg/g) was observed in the MODY3 group. The mean stool E1 elastase level in the HNF-1alpha MODY group was significantly lower than in the control subjects (401.0 +/- 118.4 vs. 482.7 +/- 151.1 microg/g, P = 0.001). Similarly, E1 levels in T1DM were lower than in control subjects (344.8 +/- 132.1 microg/g, P = 0.001); one patient with a moderate enzyme decrease was identified in this group. In addition, more frequent GI complaints were reported by HNF-1alpha MODY patients when compared with control subjects and also with T1DM patients. CONCLUSION: Pancreatic exocrine insufficiency is not common in HNF-1alpha MODY diabetic patients, although their stool E1 levels are lower than in healthy control subjects.
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Authors | T Klupa, J Skupień, S Gorczynska-Kosiorz, K Wanic, B Kusnierz-Cabala, B Solnica, J Sieradzki, M T Malecki |
Journal | Diabetic medicine : a journal of the British Diabetic Association
(Diabet Med)
Vol. 25
Issue 5
Pg. 627-30
(May 2008)
ISSN: 1464-5491 [Electronic] England |
PMID | 18445177
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Hepatocyte Nuclear Factor 1
- Pancreatic Elastase
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Topics |
- Adult
- Diabetes Mellitus, Type 1
(enzymology)
- Diabetes Mellitus, Type 2
(enzymology)
- Exocrine Pancreatic Insufficiency
(enzymology, etiology)
- Feces
(enzymology)
- Female
- Hepatocyte Nuclear Factor 1
(metabolism)
- Humans
- Male
- Pancreas
(enzymology)
- Pancreatic Elastase
(deficiency)
- Surveys and Questionnaires
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