Abstract | BACKGROUND: METHODS:
Steroid hormone metabolites in 24-h urine samples of 165 consecutive hypertensive patients were analyzed for F and cortisone (E), and their TH-metabolites tetrahydro-F (THF), 5alphaTHF, TH-deoxycortisol (THS), and THE by gas chromatography-mass spectroscopy. Apparent 11beta-HSD2 and 11beta-hydroxylase activity and excretion of F metabolites were assessed. RESULTS: In 72 female and 93 male patients aged 18-84 years, age correlated positively with the ratios of (THF + 5alphaTHF)/THE (P = 0.065) and F/E (P < 0.002) suggesting an age-dependent reduction in the apparent 11beta-HSD2 activity, which persisted (F/E; P = 0.020) after excluding impaired renal function. Excretion of F metabolites remained age-independent most likely as a consequence of an age-dependent diminished apparent 11beta-hydroxylase activity (P = 0.038). CONCLUSION: Reduced 11beta-HSD2 activity emerges as a previously unrecognized risk factor contributing to the rising prevalence of arterial hypertension in elderly. This opens new perspectives for targeted treatment of age-related hypertension.
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Authors | Jana Henschkowski, Andreas E Stuck, Brigitte M Frey, Gerhard Gillmann, Bernhard Dick, Felix J Frey, Markus G Mohaupt |
Journal | American journal of hypertension
(Am J Hypertens)
Vol. 21
Issue 6
Pg. 644-9
(Jun 2008)
ISSN: 0895-7061 [Print] United States |
PMID | 18443572
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- 11-beta-Hydroxysteroid Dehydrogenase Type 2
- Hydrocortisone
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Topics |
- 11-beta-Hydroxysteroid Dehydrogenase Type 2
(urine)
- Adolescent
- Adult
- Age Factors
- Aged
- Aged, 80 and over
- Female
- Humans
- Hydrocortisone
(blood)
- Hypertension
(blood, enzymology)
- Male
- Middle Aged
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