Abstract | AIM: MATERIAL AND METHODS: A comparative randomized trial of fenspiride used for 6 months in combination with broncholytic drugs enrolled 68 COPD patients. A clinical status, external respiration function were examined. Quality of life was evaluated with WHO questionnaire WHOQOL-100. RESULTS: Addition of fenspiride to combined treatment of COPD attenuates COPD symptoms, normalizes blood biochemistry, improves external respiration function, raises exercise tolerance. Quality of life improved by physical and mental state scales. CONCLUSION:
Fenspiride addition to COPD treatment improves efficacy of the standard treatment and is recommended for treatment of COPD of stage I and II in combination with broncholytic drugs.
|
Authors | S I Butorov, I V Butorov, N I Bodrug, S I Krushka, E F Tofan |
Journal | Terapevticheskii arkhiv
(Ter Arkh)
Vol. 80
Issue 3
Pg. 24-8
( 2008)
ISSN: 0040-3660 [Print] Russia (Federation) |
PMID | 18441679
(Publication Type: Comparative Study, English Abstract, Journal Article, Randomized Controlled Trial)
|
Chemical References |
- Anti-Asthmatic Agents
- Bronchodilator Agents
- Spiro Compounds
- fenspiride
|
Topics |
- Adult
- Ambulatory Care
(methods)
- Anti-Asthmatic Agents
- Bronchodilator Agents
(therapeutic use)
- Exercise Tolerance
(physiology)
- Female
- Humans
- Male
- Middle Aged
- Pulmonary Disease, Chronic Obstructive
(drug therapy, physiopathology, psychology)
- Quality of Life
- Spiro Compounds
(therapeutic use)
- Surveys and Questionnaires
- Treatment Outcome
- Vital Capacity
(physiology)
|