Abstract | INTRODUCTION: OBSERVATION: We describe the outcome of bilateral DBS of the internal pallidum in a 46-year-old woman suffering from MSA that initially resembled Parkinson's disease with prominent levodopa-induced dyskinesias. DBS of the left internal pallidum was performed in 1998 after a ten-year clinical course and improved dyskinesias. Six months later, the right side was implanted. A few months after the second surgery, the patient progressively developed signs of cerebellar and dysautonomic impairment and MSA was diagnosed. CONCLUSION: Our observation confirms the ineffectiveness of DBS of the internal pallidum in MSA and even suggests a harmful effect. DBS remains contra-indicated in atypical parkinsonism.
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Authors | V Lambrecq, E Krim, W Meissner, D Guehl, F Tison |
Journal | Revue neurologique
(Rev Neurol (Paris))
Vol. 164
Issue 4
Pg. 398-402
(Apr 2008)
ISSN: 0035-3787 [Print] France |
Vernacular Title | Stimulation cérébrale profonde du pallidum interne dans l'atrophie multisystématisée. |
PMID | 18439935
(Publication Type: Case Reports, English Abstract, Journal Article)
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Topics |
- Deep Brain Stimulation
(adverse effects)
- Dyskinesias
(etiology, therapy)
- Electrodes, Implanted
- Female
- Globus Pallidus
(physiology)
- Humans
- Middle Aged
- Multiple System Atrophy
(therapy)
- Neurologic Examination
- Neuropsychological Tests
- Treatment Failure
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