Abstract | OBJECTIVE: DESIGN: Cross-sectional cohort analysis. SETTING: Academic medical center. PATIENT(S): Three hundred fifty-two women with PCOS. INTERVENTION(S): Patients presenting for evaluation of symptoms related to androgen excess were evaluated physically and biochemically through laboratory analysis. MAIN OUTCOME MEASURE(S): RESULT(S): Bivariate analysis indicated that all parameters were associated with HOMA-IR, except 17-OHP and age, and confirmed a negative correlation between DHEAS and HOMA-IR. Multivariate analysis indicated that increases in DHEAS, SHBG, 17-OHP, and age were associated with decreasing HOMA-IR, whereas increases in free T, body mass index (BMI), and waist-to-hip ratio (WHR) were associated with increasing HOMA-IR. In decreasing order of importance, the following variables predicted insulin resistance: BMI > WHR > age > DHEAS > free T > SHBG > 17-OHP. CONCLUSION(S): DHEAS is negatively correlated to insulin resistance in patients with PCOS, and in our model ranked just behind other well-established predictors including BMI, WHR, and age. Whether this is due to a direct beneficial effect on insulin action by adrenal androgens such as DHEA, or whether DHEAS simply reflects the circulating levels of hyperinsulinemia, remains to be determined.
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Authors | Kathleen Brennan, Andy Huang, Ricardo Azziz |
Journal | Fertility and sterility
(Fertil Steril)
Vol. 91
Issue 5
Pg. 1848-52
(May 2009)
ISSN: 1556-5653 [Electronic] United States |
PMID | 18439591
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Chemical References |
- Sex Hormone-Binding Globulin
- Testosterone
- Dehydroepiandrosterone Sulfate
- 17-alpha-Hydroxyprogesterone
|
Topics |
- 17-alpha-Hydroxyprogesterone
(blood)
- Adult
- Body Mass Index
- Cohort Studies
- Cross-Sectional Studies
- Dehydroepiandrosterone Sulfate
(blood)
- Female
- Humans
- Insulin Resistance
- Polycystic Ovary Syndrome
- Sex Hormone-Binding Globulin
(analysis)
- Testosterone
(blood)
- Waist-Hip Ratio
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