Abstract |
Exacerbation of hypoxic injury after reoxygenation is a crucial mechanism mediating organ injury in transplantation, and in myocardial, hepatic, gastrointestinal, cerebral, renal, and other ischemic syndromes. The occlusion and reperfusion of the splanchnic artery is a useful animal model to elucidate the mechanism of gastrointestinal injury induced by ischemia-reperfusion (I/R). Although xanthine oxidase is a major source of reactive oxygen species (ROS), which plays an important role in the I/R-induced intestinal injury, there are many other sources of intracellular ROS. Various treatment modalities have been successfully applied to attenuate the I/R injury in animal models. This review focuses on the role of oxidant stress in the mechanism of I/R injury and the use of antioxidant agents for its treatment.
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Authors | Makoto Sasaki, Takashi Joh |
Journal | Journal of clinical biochemistry and nutrition
(J Clin Biochem Nutr)
Vol. 40
Issue 1
Pg. 1-12
(Jan 2007)
ISSN: 0912-0009 [Print] Japan |
PMID | 18437208
(Publication Type: Journal Article)
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