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Sphingomyelinase deficiency (Niemann-Pick disease) in a Hereford calf.

Abstract
A 5-month-old Hereford calf with neurologic disease was euthanatized, and a necropsy was done. No gross lesions were seen in the brain. Microscopically, neurons throughout the brain and spinal cord had distended, foamy vacuolated cytoplasm. Ultrastructure showed clear vacuoles filling the neuronal cytoplasm. A lysosomal storage disease was suspected. Sphingomyelinase deficiency was confirmed by biochemical analysis of liver and brain.
AuthorsG K Saunders, D A Wenger
JournalVeterinary pathology (Vet Pathol) Vol. 45 Issue 2 Pg. 201-2 (Mar 2008) ISSN: 0300-9858 [Print] United States
PMID18424834 (Publication Type: Case Reports, Journal Article, Research Support, N.I.H., Extramural)
Topics
  • Animals
  • Brain (pathology, ultrastructure)
  • Cattle
  • Cattle Diseases (pathology)
  • Fatal Outcome
  • Histocytochemistry (veterinary)
  • Male
  • Microscopy, Electron (veterinary)
  • Niemann-Pick Diseases (pathology, veterinary)
  • Spinal Cord (pathology, ultrastructure)

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