Abstract | OBJECTIVE: DESIGN AND METHODS: RESULTS: PON1's activities were decreased in cancer. Arylesterase activity correlated with cancer T and N stages, being an N1-independent predictor. Both activities correlated with transferrin, albumin, CRP and inflammation-based Glasgow Prognostic Score, and arylesterase activity also with interleukin-6 and midkine. Phenotype A (Q192 homozygotes) was associated with lower transferrin and higher TNF-alpha concentrations. PON1's arylesterase activity reflected anemia severity, being correlated with hemoglobin, hematocrit, and iron. PON1 arylesterase activity negatively correlated with alkaline phosphatase and gamma-glutamyl transferase, but not with bilirubin, aminotransferases, HDL or LDL cholesterol. PON1 moderately indicated cancer presence and regional metastasis. CONCLUSIONS: PON1 activity decreases in gastroesophageal cancers and corresponds to inflammation severity and cancer-related anemia. PON1 decrease indicates lymph node metastasis, but its moderate predictive power does not recommend PON1 determination alone for clinical application.
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Authors | Malgorzata Krzystek-Korpacka, Dorota Boehm, Malgorzata Matusiewicz, Dorota Diakowska, Krzysztof Grabowski, Andrzej Gamian |
Journal | Clinical biochemistry
(Clin Biochem)
Vol. 41
Issue 10-11
Pg. 804-11
(Jul 2008)
ISSN: 1873-2933 [Electronic] United States |
PMID | 18423402
(Publication Type: Journal Article)
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Chemical References |
- Aryldialkylphosphatase
- PON1 protein, human
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Topics |
- Adenocarcinoma
(complications, enzymology, physiopathology)
- Adult
- Aged
- Aged, 80 and over
- Anemia
(blood, enzymology, etiology)
- Aryldialkylphosphatase
(blood)
- Carcinoma, Squamous Cell
(complications, enzymology, physiopathology)
- Esophageal Neoplasms
(complications, enzymology, pathology, physiopathology)
- Female
- Humans
- Inflammation
(enzymology, etiology)
- Male
- Middle Aged
- Neoplasm Staging
- Paraneoplastic Syndromes
(enzymology, etiology, pathology, physiopathology)
- Stomach Neoplasms
(complications, enzymology, pathology, physiopathology)
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