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Rizatriptan efficacy in ICHD-II pure menstrual migraine and menstrually related migraine.

AbstractOBJECTIVE:
To examine the efficacy of rizatriptan for the treatment of pure menstrual migraine (PMM).
BACKGROUND:
In 2004, the International Headache Society proposed new research criteria for menstrual migraine (International Classification of Headache Disorders [ICHD-II]). Two subtypes were defined: PMM, in which attacks occur exclusively with menstruation, and menstrually related migraine (MRM), in which attacks may also occur at other times of the cycle.
METHODS:
The 2 protocols (MM1 and MM2) were identical randomized, double-blind studies. Adult patients with ICHD-II menstrual migraine were assigned to either rizatriptan 10-mg tablet or placebo (2:1). Patients were to treat a single menstrual migraine attack of moderate or severe pain intensity. This prospectively planned substudy pooled data from patients with a diagnosis of PMM from both studies. The primary substudy endpoint was 2-hour pain relief. Efficacy data were summarized for patients with a diagnosis of MRM.
RESULTS:
Of 707 (MM1: 357, MM2: 350) patients treated in the study, 146 patients (MM1: 81, MM2: 65) had a diagnosis of PMM. The percentage of patients reporting 2-hour pain relief was significantly greater for rizatriptan than for placebo for both PMM (73% vs 50%, P = .006) and MRM subgroups (71% vs 52%, P < .001). Most other efficacy endpoints favored rizatriptan compared with placebo in patients with either PMM or MRM.
CONCLUSION:
Rizatriptan 10 mg was superior to placebo for the treatment of PMM, as measured by 2-hour pain relief. Rizatriptan was also effective for the treatment of MRM and for relief of migraine-associated symptoms for both headache subtypes.
AuthorsRobert Nett, Lisa K Mannix, Loretta Mueller, Anthony Rodgers, Carolyn M Hustad, Franck Skobieranda, Karen E Ramsey
JournalHeadache (Headache) Vol. 48 Issue 8 Pg. 1194-201 (Sep 2008) ISSN: 1526-4610 [Electronic] United States
PMID18422606 (Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
Chemical References
  • Serotonin Receptor Agonists
  • Triazoles
  • Tryptamines
  • rizatriptan
Topics
  • Adolescent
  • Adult
  • Clinical Protocols
  • Disability Evaluation
  • Double-Blind Method
  • Female
  • Humans
  • Menstruation Disturbances (complications, drug therapy)
  • Migraine Disorders (drug therapy, etiology)
  • Pain Measurement
  • Prospective Studies
  • Retrospective Studies
  • Serotonin Receptor Agonists (therapeutic use)
  • Treatment Outcome
  • Triazoles (therapeutic use)
  • Tryptamines (therapeutic use)
  • Young Adult

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