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Omega-3 fatty acid concentrates in the treatment of moderate hypertriglyceridemia.

AbstractBACKGROUND:
Moderate hypertriglyceridemia is fairly common, and elevated triglycerides are a risk factor for coronary heart disease. The omega-3 fatty acids EPA and DHA have been shown to lower triglycerides in many clinical studies. Prescription omega-3 fatty acid concentrates (P-OM3) are indicated for use in people with very high triglycerides (> 500 mg/dl). Current guidelines recommend that triglycerides should be less < 150 mg/dl.
OBJECTIVE:
This review provides an overview of the use of omega-3 concentrates (both P-OM3 and over-the-counter fish oil) to lower triglycerides in people who have moderate hypertriglyceridemia (triglycerides in the range of 150 - 500 mg/dl). The objectives were to examine clinical evidence, describe the magnitude of effects and predict future clinical use of P-OM3.
METHODS:
Published, peer-reviewed studies of omega-3 concentrates were included if they were placebo-controlled, double-blind, of sufficient size to demonstrate triglyceride lowering, and studied a population described as having a mean baseline triglyceride value of 150 - 500 mg/dl. Studies using the 4-g dose of P-OM3 were used to develop a model of percent triglyceride lowering as a function of baseline levels.
RESULTS/CONCLUSIONS:
P-OM3 are effective in reducing triglycerides by approximately 30% in this population and are likely to be combined with other drugs (e.g., statins) to treat combined dyslipidemia.
AuthorsAnn C Skulas-Ray, Sheila G West, Michael H Davidson, Penny M Kris-Etherton
JournalExpert opinion on pharmacotherapy (Expert Opin Pharmacother) Vol. 9 Issue 7 Pg. 1237-48 (May 2008) ISSN: 1744-7666 [Electronic] England
PMID18422480 (Publication Type: Journal Article, Review)
Chemical References
  • Fish Oils
  • Docosahexaenoic Acids
  • Eicosapentaenoic Acid
Topics
  • Coronary Disease (drug therapy, etiology)
  • Docosahexaenoic Acids (adverse effects, pharmacology, therapeutic use)
  • Eicosapentaenoic Acid (adverse effects, pharmacology, therapeutic use)
  • Fish Oils (therapeutic use)
  • Humans
  • Hypertriglyceridemia (drug therapy)
  • Practice Guidelines as Topic
  • Randomized Controlled Trials as Topic
  • Risk Factors
  • Severity of Illness Index

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