Intrahepatic splenosis with severe iron deposition presenting with atypical magnetic resonance images.

Abstract

An intrahepatic mass was incidentally found in a 41-year-old man with a history of a traffic accident injury which resulted in removal of a ruptured spleen. Hepatic splenosis was considered in the differential diagnosis but magnetic resonance imaging showed hypointensity on T2-weighted images, atypical for normal spleen. Histologically, the mass showed sinusoidal structures and lymphoid follicular aggregates. Immunohistochemical study showed that the phenotype of the vascular lining cells was CD8-positive, CD31-positive, and CD34 negative, the pattern diagnostic for ectopic spleen. In addition, severe iron deposition was histologically demonstrated, which was considered as the cause of the hypointense T2-weighted images.

• Authors: Tomoki Nakajima, Atsushi Fujiwara, Mio Yamaguchi, Akiko Makiyama, Takeshi Wakae, Kinya Fujita, Kenji Yoshikawa, Takehiko Shiomi, Tohru Ohishi, Toshiaki Nakashima, Eiichi Konishi
• Journal: Internal medicine (Tokyo, Japan) (Intern Med) Vol. 47 Issue 8 Pg. 743-6 ( 2008) ISSN: 1349-7235 [Electronic] Japan
• PMID: 18421191 (Publication Type: Case Reports, Journal Article)

Chemical References

• Iron

Topics

• Adult
• Biopsy
• Choristoma (diagnosis, metabolism, pathology)
• Diagnosis, Differential
• Humans
• Iron (metabolism)
• Liver (metabolism, pathology)
• Liver Diseases (diagnosis, metabolism, pathology)
• Liver Neoplasms (diagnosis, pathology)
• Magnetic Resonance Imaging
• Male
• Spleen
• Splenosis (diagnosis, metabolism, pathology)