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Pituitary and ovarian response to acute stimulation with LH-RH in normal and anovulatory women.

Abstract
The LH FSH estradiol and progesterone responses to acute stimulation with LH-RH were studied in 12 normal women with ovulatory cycles (4 in the initial follicular phase, 4 in the mid-follicular phase and 4 in the late follicular phase) and in two castrated women, two under hormonal contraception, two with ovarian amenorrhea, twelve with central amenorrhea of no detectable origin (6 with normal and 6 with low basal gonadotrophins), eleven anovulatory patients with pseudomenstruation, two with anorexia nervosa, and two with pituitary amenorrhea. Each woman received a rapid i.v. injection of 100 microgram synthetic LH-RH at 9:00 a.m. Serum levels of LH, FSH, estradiol and progesterone were determined by radioimmunoassay in samples collected before and 60, 120, 240 and 480 minutes after injection. The findings were : 1) A significant rise in estradiol and progesterone levels, in addition to LH and FSH elevation, in normal women; 2) A lack of ovarian steroid response in the castrated women and in ovarian amenorrheas, which suggests that the source of steroid response to stimulation is not extragonadal; 3) Significant differences in the responses of the four hormones to LH-RH in the women with central amenorrhea in comparison with the normal group with great variability of results; the steroid response in the presence of a positive LH response might correlate with the severity and/or prognosis of the disorder, a point deserving further study; 4) In anovulatory women with pseudomenstruation, LH responses for the most part normal, and particularly, progesterone responses.
AuthorsN J Aparicio, P R Casas, D M Galimberti, N P de Laborde, A Badano, E P García, H R Meichi, A Mirkin, M Szejner, A Jaitt, M Margulies, J M Rosner
JournalInternational journal of fertility (Int J Fertil) Vol. 22 Issue 1 Pg. 6-15 ( 1977) ISSN: 0020-725X [Print] United States
PMID18416 (Publication Type: Journal Article)
Chemical References
  • Contraceptives, Oral
  • Gonadotropin-Releasing Hormone
  • Progesterone
  • Estradiol
  • Luteinizing Hormone
  • Follicle Stimulating Hormone
Topics
  • Adult
  • Amenorrhea (physiopathology)
  • Anovulation (physiopathology)
  • Castration
  • Contraceptives, Oral
  • Estradiol (metabolism)
  • Female
  • Follicle Stimulating Hormone (metabolism)
  • Gonadotropin-Releasing Hormone
  • Humans
  • Luteinizing Hormone (metabolism)
  • Ovary (physiopathology)
  • Ovulation (drug effects)
  • Pituitary Gland (physiopathology)
  • Pituitary Gland, Anterior (physiopathology)
  • Progesterone (metabolism)

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