Abstract |
Kangai (KAI)-1 (CD82) is a metastasis suppressor gene, which belongs to the family of tetraspanin proteins. A loss of KAI-1 expression is associated with the advanced stages of many human malignancies. The present study was designed to investigate the expression pattern of KAI-1 in the normal endometrium and uterine tumors and to correlate it with the expression of tumor suppressor protein p53. KAI-1 could be found in the normal endometrium throughout the menstrual cycle. Thirteen of 42 endometrial carcinomas demonstrated moderate KAI-1 expression, but low expression of p53. Twenty-nine of 42 endometrial carcinomas showed reduced or absent KAI-1 expression, which correlated with strong expression of p53 (p < 0.001). There were significant correlations between KAI-1 expression and histological type, e.g., 93% of endometrioid carcinomas displayed a low or moderate immunostaining for KAI-1, whereas nearly all of the serous/clear cell carcinomas were KAI-1 negative (p < 0.001); tumor grading, e.g., 73% of high grade tumors showed no KAI-1 expression (p < 0.001). Most of the investigated uterine sarcomas were negative for KAI-1, whereas they displayed a strong immunostaining for p53. In conclusion, KAI-1 and p53 show inverse expression. The reduced KAI-1 expression may be the result of dysregulated p53 function and could be an important step in the endometrial carcinogenesis.
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Authors | Juliane Briese, Heinrich M Schulte, Maria Sajin, Christoph Bamberger, Katja Redlin, Karin Milde-Langosch, Thomas Löning, Ana-Maria Bamberger |
Journal | Virchows Archiv : an international journal of pathology
(Virchows Arch)
Vol. 453
Issue 1
Pg. 89-96
(Jul 2008)
ISSN: 0945-6317 [Print] Germany |
PMID | 18415123
(Publication Type: Journal Article)
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Chemical References |
- Biomarkers, Tumor
- Kangai-1 Protein
- RNA, Messenger
- Tumor Suppressor Protein p53
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Topics |
- Adenocarcinoma, Clear Cell
(metabolism, pathology)
- Adult
- Aged
- Aged, 80 and over
- Biomarkers, Tumor
(metabolism)
- Carcinoma, Endometrioid
(metabolism, pathology)
- Carcinosarcoma
(metabolism, pathology)
- Endometrial Hyperplasia
(metabolism, pathology)
- Endometrial Neoplasms
(metabolism, pathology)
- Female
- Gene Expression Regulation, Neoplastic
- Humans
- Kangai-1 Protein
(metabolism)
- Leiomyosarcoma
(metabolism, pathology)
- Middle Aged
- RNA, Messenger
(metabolism)
- Sarcoma
(metabolism, pathology)
- Sarcoma, Endometrial Stromal
(metabolism, pathology)
- Tumor Suppressor Protein p53
(metabolism)
- Uterine Neoplasms
(metabolism, pathology)
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