Carbon 11-labeled pittsburgh compound B positron emission tomographic amyloid imaging in patients with APP locus duplication.

Abstract

OBJECTIVE:

To investigate amyloid accumulation by carbon 11-labeled Pittsburgh Compound B (11C-PiB) in hereditary cerebral amyloid angiopathy and APP locus duplication.

DESIGN, SETTING, AND PATIENTS:

Positron emission tomography with 11C-PiB and magnetic resonance imaging were performed for 2 patients, 49-year-old and 60-year-old siblings with APP locus duplication, with hereditary Alzheimer disease and cerebral amyloid angiopathy.

MAIN OUTCOME MEASURE:

Change in 11C-PiB uptake.

RESULTS:

Uptake of 11C-PiB was increased especially in the striatum (caudate nucleus to 225% and 280% of the control mean and putamen to 166% and 185% of the control mean) and in the posterior cingulate (to 168% and 198% of the control mean), and it was marginally increased in other cortical brain areas. The pattern of increased 11C-PiB uptake was different from that seen in sporadic Alzheimer disease.

CONCLUSIONS:

Amyloid imaging with 11C-PiB positron emission tomography is a useful tool for detecting in vivo amyloid accumulation in patients with hereditary cerebral amyloid angiopathy. However, the pattern of 11C-PiB accumulation differs between patients with typical AD and patients with APP locus duplication.

• Authors: Anne M Remes, Lauri Laru, Hannu Tuominen, Sargo Aalto, Nina Kemppainen, Helinä Mononen, Kjell Någren, Riitta Parkkola, Juha O Rinne
• Journal: Archives of neurology (Arch Neurol) Vol. 65 Issue 4 Pg. 540-4 (Apr 2008) ISSN: 1538-3687 [Electronic] United States
• PMID: 18413480 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• 2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole
• APP protein, human
• Amyloid beta-Protein Precursor
• Aniline Compounds
• Carbon Radioisotopes
• Protease Nexins
• Receptors, Cell Surface
• Thiazoles

Topics

• Alzheimer Disease (diagnostic imaging, genetics)
• Amyloid beta-Protein Precursor (genetics, metabolism)
• Aniline Compounds
• Brain (diagnostic imaging)
• Carbon Radioisotopes
• Caudate Nucleus (diagnostic imaging)
• Cerebral Amyloid Angiopathy, Familial (diagnostic imaging, genetics)
• Dominance, Cerebral (physiology)
• Female
• Gene Duplication
• Gyrus Cinguli (diagnostic imaging)
• Hippocampus (diagnostic imaging)
• Humans
• Image Processing, Computer-Assisted
• Magnetic Resonance Imaging
• Male
• Mental Status Schedule
• Middle Aged
• Neuropsychological Tests
• Parietal Lobe (diagnostic imaging)
• Positron-Emission Tomography
• Protease Nexins
• Putamen (diagnostic imaging)
• Receptors, Cell Surface (genetics, metabolism)
• Sensitivity and Specificity
• Temporal Lobe (diagnostic imaging)
• Thiazoles