Abstract | INTRODUCTION AND OBJECTIVES:
Drug-eluting stents (DES) have proven to be effective in reducing the rate of restenosis and have, therefore, been incorporated into the treatment of patients with ST-elevation acute myocardial infarction ( STEMI). The aim of this study was to investigate long-term clinical and angiographic outcomes following the use of DESs in patients with STEMI. METHODS: A prospective study involving clinical and angiographic follow-up was performed in 81 patients with STEMI who underwent percutaneous coronary intervention including DES implantation. This group was compared with 82 patients with similar characteristics who were treated with bare- metal stents (BMS) in an earlier period. RESULTS: At one year, there was no significant difference between the groups in the mortality (2.5% in the DES group vs 7.3% in the BMS group; P=.15) or reinfarction rate (4.8% in the DES group vs. 4.8% in the BMS group; P=.98). The target lesion revascularization rate was significantly lower in the DES group (8.6% vs 23.2% in the BMS group; P=.001), as was the restenosis rate (13.8% vs. 30.9% in the BMS group; P=.02). Acute or subacute stent thrombosis was diagnosed in five patients (3 with a DES and 2 with a BMS; P=.64), and one late stent thrombosis was detected after a year, in a sirolimus-eluting stent. CONCLUSIONS: Implantation of a DES in patients with STEMI did not result in a reduction in either the mortality or reinfarction rate at 1 year compared with BMS implantation. However, there were reductions in the rates of restenosis and target lesion revascularization. The incidence of thrombosis was similar with the two types of stent.
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Authors | Ana M Planas-Del Viejo, Francisco Pomar-Domingo, Juan V Vilar-Herrero, Victoria Jacas-Osborn, Mercedes Nadal-Barangé, Emilio Pérez-Fernández |
Journal | Revista espanola de cardiologia
(Rev Esp Cardiol)
Vol. 61
Issue 4
Pg. 360-8
(Apr 2008)
ISSN: 1579-2242 [Electronic] Spain |
Vernacular Title | Resultados clínicos y angiográficos tardíos de stents liberadores de fármacos en pacientes con infarto agudo de miocardio con elevación del ST. |
PMID | 18405516
(Publication Type: Journal Article)
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Topics |
- Coronary Angiography
- Cross-Sectional Studies
- Drug-Eluting Stents
- Female
- Follow-Up Studies
- Humans
- Male
- Middle Aged
- Myocardial Infarction
(diagnostic imaging, physiopathology, surgery)
- Prospective Studies
- Time Factors
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