Abstract |
The common adverse effect of centrally-injected mu-opioid receptor (mu-OR) agonists is pruritus. This study was conducted using mice to examine whether different subtypes of mu-OR would be responsible for pruritus and analgesia. Intracisternal injections of morphine and morphine-6beta-glucronide (M6G), but not M3G, produced an antinociceptive effect. Morphine, but neither M6G nor M3G, induced facial scratching, a pruritus-related response. Facial scratching following morphine was not affected by the mu(1)-OR antagonist naloxonazine at doses that inhibited the antinociceptive effects. The results suggest that different subtype and/or splice variants of mu-OR are separately involved in pruritus and antinociception of opioids.
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Authors | Tsugunobu Andoh, Yuichi Yageta, Mitsuhiro Konno, Tomomi Yamaguchi-Miyamoto, Hiroki Takahata, Hiroshi Nojima, Hideo Nemoto, Yasushi Kuraishi |
Journal | Journal of pharmacological sciences
(J Pharmacol Sci)
Vol. 106
Issue 4
Pg. 667-70
(Apr 2008)
ISSN: 1347-8613 [Print] Japan |
PMID | 18403901
(Publication Type: Journal Article)
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Chemical References |
- Analgesics, Opioid
- Morphine Derivatives
- Narcotic Antagonists
- Oprm protein, mouse
- Receptors, Opioid, mu
- Naloxone
- morphine-6-glucuronide
- Morphine
- naloxonazine
- morphine-3-glucuronide
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Topics |
- Analgesics, Opioid
(administration & dosage, toxicity)
- Animals
- Behavior, Animal
(drug effects)
- Dose-Response Relationship, Drug
- Injections, Subcutaneous
- Male
- Mice
- Mice, Inbred ICR
- Morphine
(administration & dosage, toxicity)
- Morphine Derivatives
(administration & dosage)
- Naloxone
(administration & dosage, analogs & derivatives)
- Narcotic Antagonists
(administration & dosage)
- Pain Measurement
- Pain Threshold
(drug effects)
- Pruritus
(chemically induced, metabolism, prevention & control)
- Receptors, Opioid, mu
(agonists, metabolism)
- Time Factors
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