Abstract | OBJECTIVE: METHODS: We detected expression of Glut-1 and -3 in 38 HNCs and analyzed the relationship between increased expression and the biological behavior of HNCs. RESULTS: The gene expression levels of Glut-1 and -3 in HNCs were significantly higher than those in adjacent cancer tissues or in normal tissues. The GLUT-1 gene level was correlated with the lymph node metastasis and clinical stage of 38 HNCs, and the GLUT-3 gene level was correlated with the lymph node metastasis of 38 HNCs. Of the 38 cases, 30 showed positive expression of Glut-1 protein. The Glut-1 protein expression level was related to the lymph node metastasis and clinical stage of 38 HNCs. However, there was no case that expressed Glut-3 protein. The high expression of Glut-1 gene and protein was associated with poor survival in the HNCs. GLUT-3 gene expression was not associated with the prognosis of HNCs. CONCLUSIONS: GLUT-1 gene expression level and protein expression were correlated with lymph node metastasis, poor survival and clinical stage of HNCs. The GLUT-3 gene expression level was high in HNCs, and its expression was associated with an increased incidence of lymph node metastasis of HNCs.
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Authors | Shuihong Zhou, Shenqing Wang, Qiuliang Wu, Jun Fan, Qinying Wang |
Journal | ORL; journal for oto-rhino-laryngology and its related specialties
(ORL J Otorhinolaryngol Relat Spec)
Vol. 70
Issue 3
Pg. 189-94
( 2008)
ISSN: 1423-0275 [Electronic] Switzerland |
PMID | 18401196
(Publication Type: Journal Article)
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Copyright | 2008 S. Karger AG, Basel |
Chemical References |
- Glucose Transporter Type 1
- Glucose Transporter Type 3
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Topics |
- Adult
- Aged
- Carcinoma
(metabolism, pathology, physiopathology, secondary)
- Female
- Gene Expression
- Glucose Transporter Type 1
(metabolism)
- Glucose Transporter Type 3
(metabolism)
- Head and Neck Neoplasms
(metabolism, pathology, physiopathology)
- Humans
- Immunohistochemistry
- Kaplan-Meier Estimate
- Lymphatic Metastasis
- Male
- Middle Aged
- Neoplasm Staging
- Reverse Transcriptase Polymerase Chain Reaction
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