Abstract |
Fourteen patients with advanced/recurrent squamous cell carcinoma of the uterine cervix received menogaril, 200 mg/m2 by one hour intravenous infusion at four-week intervals. No objective regressions were observed. Median time to progression was less than two months and median survival was seven months. All patients experienced neutropenia. Platelet toxicity was negligible. Venous irritation and phlebitis occurred at the infusion site in 43% of patients. Menogaril as administered in this protocol is ineffective in treating previously irradiated advanced/recurrent squamous cell carcinoma of the uterine cervix and warrants no further investigation in this disease at the dosage and administration schedule used in this protocol.
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Authors | H J LONG 3rd, H S Wieand, J F Foley, R D Niedringhaus, J A Laurie, R F Morton, R M Goldberg, J A Mailliard, G D Malkasian, J H Edmonson |
Journal | Investigational new drugs
(Invest New Drugs)
Vol. 9
Issue 4
Pg. 349-51
(Nov 1991)
ISSN: 0167-6997 [Print] United States |
PMID | 1839536
(Publication Type: Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Antineoplastic Agents
- Menogaril
- Nogalamycin
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Topics |
- Adult
- Aged
- Antineoplastic Agents
(therapeutic use)
- Carcinoma, Squamous Cell
(drug therapy)
- Drug Evaluation
- Female
- Humans
- Menogaril
- Middle Aged
- Neoplasm Recurrence, Local
(drug therapy)
- Nogalamycin
(analogs & derivatives, therapeutic use)
- Uterine Cervical Neoplasms
(drug therapy)
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