Polymorphism in the sorbin and SH3-domain-containing-1 (SORBS1) gene and the risk of brain infarction in the Japanese population: the Fukuoka Stroke Registry and the Hisayama study.

Abstract

BACKGROUND AND PURPOSE:

Sorbin and SH3-domain-containing-1 (SORBS1) is an important adaptor protein in insulin-signalling pathway, and its genetic polymorphism may regulate the activity of insulin resistance. We investigated the association between the SORBS1 T228A polymorphism and ischaemic stroke.

METHODS:

Genotyping was achieved by a rapid-cycle PCR and melting curve analysis using fluorescent probes in 1049 incident cases of ischaemic stroke and 1049 age- and sex-matched control subjects recruited from the Hisayama study.

RESULTS:

The allele distributions of the SORBS1 T228A polymorphism were similar amongst cases and controls. The multivariate-adjusted odds ratio (OR) of the AA genotype for ischaemic stroke was 2.897 (95% CI, 0.907-8.018) compared with the TT genotype. In terms of stroke subtype, there was a trend toward a difference in the AA genotypes for lacunar infarction, compared with the TT genotype (OR = 8.740, P = 0.0510), and combined TT and TA genotypes (OR = 8.768, P = 0.0505). The other polymorphisms genotyped were not associated with any subtypes of ischaemic stroke. T228A polymorphism of SORBS1 was not associated with the prevalence of diabetes.

CONCLUSIONS:

The AA genotype of SORBS1 T228A polymorphism may play a role in lacunar infarction in the Japanese population.

• Authors: N Hagiwara, T Kitazono, M Kamouchi, J Kuroda, T Ago, J Hata, T Ninomiya, H Ooboshi, Y Kumai, S Yoshimura, K Tamaki, K Fujii, T Nagao, Y Okada, K Toyoda, H Nakane, H Sugimori, Y Yamashita, Y Wakugawa, M Kubo, Y Tanizaki, Y Kiyohara, S Ibayashi, M Iida, Fukuoka Stroke Registry, Hisayama study
• Journal: European journal of neurology (Eur J Neurol) Vol. 15 Issue 5 Pg. 481-6 (May 2008) ISSN: 1468-1331 [Electronic] England
• PMID: 18394047 (Publication Type: Comparative Study, Journal Article, Multicenter Study)

Chemical References

• Microfilament Proteins
• SORBS1 protein, human

Topics

• Aged
• Brain Infarction (classification, epidemiology, genetics)
• Case-Control Studies
• Cohort Studies
• Female
• Gene Frequency
• Genetic Predisposition to Disease
• Genotype
• Humans
• Japan (epidemiology, ethnology)
• Male
• Microfilament Proteins (genetics)
• Middle Aged
• Odds Ratio
• Polymorphism, Genetic
• Registries
• Retrospective Studies
• Risk
• Risk Factors