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[Association of alpha-adducin and angiotensin converting enzyme gene polymorphisms with salt-sensitive hypertension and early renal injury].

AbstractOBJECTIVE:
To investigate the association between the alpha-adducin gene G460T, angiotensin converting enzyme (ACE) insertion/deletion (I/D) polymorphisms and salt-sensitive hypertension and early renal injury in Chinese people.
METHODS:
The case-control study was performed in 200 essential hypertension (EH) and 200 normal control subjects in China. The 200 EH patients were divided into salt-sensitive(SS= 109) and non-salt-sensitive(NSS= 91) groups according to modified Sullivan's method. The genotypes of alpha-adducin gene were determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). The ACE genotypes were determined by PCR. The urine microalbum (Alb) in 200 EH subjects was measured by radioactive immunoassay.
RESULTS:
(1) A higher frequency of alpha-adducin gene G460T TT in EH patients was observed (P< 0.05). No significant difference of the ACE gene I/D polymorphism was found between the EH patients and normal control (P> 0.05). There were significant differences in the alpha-adducin gene TT genotype and combined genotype of TT+ II between SS and NSS subjects (P< 0.05). (2) The levels of urine Alb/Cr in SS patients were significantly higher than that in NSS patients (P< 0.05); in SS group, the levels of urine Alb/Cr in ACE II and alpha-adducin gene TT genotypes were higher than that in ACE ID, DD genotype and alpha-adducin gene GT and GG genotypes. The levels of urine Alb/Cr in the group of alpha-adducin gene TT+ ACE II combined genotype were higher than that in other combined genotypes (P< 0.05).
CONCLUSION:
The alpha-adducin gene TT genotype or combined with ACE II are significantly associated with SS hypertension. The alpha-adducin gene TT and ACE II genotypes might be genetic susceptibility factors to hypertension accompanying renal injury.
AuthorsLi-hong Lu, Hui Chen, Ling Yu
JournalZhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics (Zhonghua Yi Xue Yi Chuan Xue Za Zhi) Vol. 25 Issue 2 Pg. 132-5 (Apr 2008) ISSN: 1003-9406 [Print] China
PMID18393230 (Publication Type: English Abstract, Journal Article)
Chemical References
  • Calmodulin-Binding Proteins
  • adducin
  • Peptidyl-Dipeptidase A
Topics
  • Adult
  • Albuminuria (genetics, metabolism)
  • Calmodulin-Binding Proteins (genetics)
  • Female
  • Genotype
  • Humans
  • Hypertension (genetics, metabolism)
  • Male
  • Middle Aged
  • Peptidyl-Dipeptidase A (genetics)
  • Polymerase Chain Reaction
  • Polymorphism, Genetic (genetics)
  • Polymorphism, Restriction Fragment Length (genetics)
  • Radioimmunoassay

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