Abstract | OBJECTIVE: METHODS: The case-control study was performed in 200 essential hypertension (EH) and 200 normal control subjects in China. The 200 EH patients were divided into salt-sensitive(SS= 109) and non- salt-sensitive(NSS= 91) groups according to modified Sullivan's method. The genotypes of alpha-adducin gene were determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). The ACE genotypes were determined by PCR. The urine microalbum (Alb) in 200 EH subjects was measured by radioactive immunoassay. RESULTS: (1) A higher frequency of alpha-adducin gene G460T TT in EH patients was observed (P< 0.05). No significant difference of the ACE gene I/D polymorphism was found between the EH patients and normal control (P> 0.05). There were significant differences in the alpha-adducin gene TT genotype and combined genotype of TT+ II between SS and NSS subjects (P< 0.05). (2) The levels of urine Alb/Cr in SS patients were significantly higher than that in NSS patients (P< 0.05); in SS group, the levels of urine Alb/Cr in ACE II and alpha-adducin gene TT genotypes were higher than that in ACE ID, DD genotype and alpha-adducin gene GT and GG genotypes. The levels of urine Alb/Cr in the group of alpha-adducin gene TT+ ACE II combined genotype were higher than that in other combined genotypes (P< 0.05). CONCLUSION:
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Authors | Li-hong Lu, Hui Chen, Ling Yu |
Journal | Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics
(Zhonghua Yi Xue Yi Chuan Xue Za Zhi)
Vol. 25
Issue 2
Pg. 132-5
(Apr 2008)
ISSN: 1003-9406 [Print] China |
PMID | 18393230
(Publication Type: English Abstract, Journal Article)
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Chemical References |
- Calmodulin-Binding Proteins
- adducin
- Peptidyl-Dipeptidase A
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Topics |
- Adult
- Albuminuria
(genetics, metabolism)
- Calmodulin-Binding Proteins
(genetics)
- Female
- Genotype
- Humans
- Hypertension
(genetics, metabolism)
- Male
- Middle Aged
- Peptidyl-Dipeptidase A
(genetics)
- Polymerase Chain Reaction
- Polymorphism, Genetic
(genetics)
- Polymorphism, Restriction Fragment Length
(genetics)
- Radioimmunoassay
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