Abstract | BACKGROUND: METHODS: We investigated insulin sensitivity using the gold standard hyperinsulinemic-euglycemic clamp technique in 10 young adult males born small for gestational age (SGA) who had been treated with GH during childhood (GH) in comparison with 15 males born preterm AGA (premAGA), 13 males born preterm SGA (premSGA), and 15 males born at term with normal birth weight (CON). Furthermore, we investigated the presence of the metabolic syndrome. RESULTS: CONCLUSION:
Insulin sensitivity is decreased in GH-treated SGA born males as well as in preterm born males. With respect to the SGA subjects, whether the difference results from perinatal-, postnatal-, or GH therapy-related factors are not known. With respect to the preterm born subjects, close surveillance is needed when commencing GH therapy.
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Authors | J Rotteveel, M M van Weissenbruch, H A Delemarre-Van de Waal |
Journal | European journal of endocrinology
(Eur J Endocrinol)
Vol. 158
Issue 6
Pg. 899-904
(Jun 2008)
ISSN: 1479-683X [Electronic] England |
PMID | 18390989
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Adult
- Body Weight
(drug effects, physiology)
- Glucose Clamp Technique
- Growth Hormone
(therapeutic use)
- Humans
- Infant, Newborn
- Infant, Premature
(physiology)
- Infant, Small for Gestational Age
(physiology)
- Insulin Resistance
(physiology)
- Male
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