[Effect of ursodeoxycholic acid on the characteristics of lipid metabolism in cholelithiasis and gall-bladder cholesterosis].

Abstract

The article represents data demonstrating influence of ursodeoxicholic acid on the characteristics of lipidic interchange during cholesterin assosiated diseases of biliary tract. It has been shown that hypercholesterolemias occur in 64% of cases under cholelithiasis and in 56% of cases under gall-bladder cholesterosis. Slow rising of level of total cholesterol (within 5.3-6.1 mmole/l) is registered in 68% of cases under cholelithiasis and in 69% of cases under gall-bladder cholesterosis, higher hypercholesterolemia occurs rare and doesn't exceed 2-4% of cases. Disappearance of hypercholesterolemia after 3-month course of treatment with Ursosan has been registered in 45% of patients with cholelithiasis and in 49% of patients with gall-bladder cholesterosis. Other patients showed positive dynamics, and level of total cholesterol made up in general 5.6 mmoles/l under cholelithiasis and 5.4 mmoles/l uder gall-bladder cholesterosis.

• Authors: A A Il'chenko, Iu V Drozhzhina
• Journal: Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology (Eksp Klin Gastroenterol) Issue 5 Pg. 29-34, 164 ( 2007) ISSN: 1682-8658 [Print] Russia (Federation)
• PMID: 18389594 (Publication Type: English Abstract, Journal Article, Randomized Controlled Trial)

Chemical References

• Cholagogues and Choleretics
• Ursodeoxycholic Acid
• Cholesterol

Topics

• Adult
• Aged
• Aged, 80 and over
• Cholagogues and Choleretics (administration & dosage, therapeutic use)
• Cholecystitis (blood, drug therapy, metabolism)
• Cholelithiasis (blood, drug therapy, metabolism)
• Cholesterol (blood)
• Female
• Humans
• Lipid Metabolism (drug effects)
• Male
• Middle Aged
• Treatment Outcome
• Ursodeoxycholic Acid (administration & dosage, therapeutic use)