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F2-isoprostane, inflammation, cardiac function and oxygenation in the endotoxaemic pig.

Abstract
Prostaglandins are profoundly involved in endotoxaemic shock. Twenty pigs were given endotoxin at various doses (0.063-16 microg kg(-1) h(-1)). Three non-endotoxaemic pigs served as controls. Two eicosanoids were measured in plasma (8-iso-PGF(2alpha), a free radical-mediated lipid peroxidation product, and 15-keto-dihydro-PGF(2alpha) a major metabolite of COX activity) and evaluated against the pathophysiological responses that occur during endotoxaemic shock. Endotoxin mediates an increase in both 8-iso-PGF(2alpha) and 15-keto-dihydro-PGF(2alpha). An increase in the endotoxin dose induced significant log-linear responses in 8-iso-PGF(2alpha) and 15-keto-dihydro-PGF(2alpha). Oxidative injury correlated to the TNF-alpha, IL-6, reductions in cardiac performance and to oxygen delivery and utilisation. COX-mediated inflammatory responses correlated to TNF-alpha, IL-6 and to reductions in arterial oxygen tension. Thus, oxidative injury and COX-mediated inflammation play a central role in the manifestation of endotoxaemic shock. Furthermore, formation of these eicosanoids on endotoxin-mediated alterations in pulmonary hypertension, oxygen delivery and oxygen utilisation seems to be independent of the administered endotoxin dose.
AuthorsMiklós Lipcsey, Ewa Söderberg, Samar Basu, Anders Larsson, Jan Sjölin, Mikael Aström, Mats B Eriksson
JournalProstaglandins, leukotrienes, and essential fatty acids (Prostaglandins Leukot Essent Fatty Acids) Vol. 78 Issue 3 Pg. 209-17 (Mar 2008) ISSN: 0952-3278 [Print] Scotland
PMID18387796 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • 15-keto-13,14-dihydroprostaglandin F2alpha
  • 8-epi-prostaglandin F2alpha
  • Dinoprost
Topics
  • Animals
  • Dinoprost (analogs & derivatives, blood)
  • Heart (drug effects, physiopathology)
  • Inflammation (blood)
  • Oxidative Stress
  • Shock, Septic (blood, physiopathology)
  • Sus scrofa
  • Swine

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