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Lanostane-type triterpenoids from the sclerotia of Inonotus obliquus possessing anti-tumor promoting activity.

Abstract
Two new lanostane-type triterpenoids, 1 and 2 besides two known lanostane-type triterpenoids, 3 and 4 were isolated from the sclerotia of Inonotus obliquus. Their structures were determined to be lanosta-8,23E-diene-3beta,22R,25-triol (1) and lanosta-7:9(11),23E-triene-3beta,22R,25-triol (2) by spectral data. These compounds were tested for their anti-tumor-promoting activity using a short-term in vitro assay for EBV-EA activation induced by TPA. Compounds 1, 2 and 4 were stronger than the positive control, oleanolic acid. The most abundant compound 4 was investigated for the inhibitory effect in a two-stage carcinogenesis test on mouse skin using DMBA as an initiator and TPA as a promoter. Compound 4 was found to exhibit the potent anti-tumor promoting activity in the in vivo carcinogenesis test.
AuthorsSayaka Taji, Takeshi Yamada, Shun-Ichi Wada, Harukuni Tokuda, Kazuo Sakuma, Reiko Tanaka
JournalEuropean journal of medicinal chemistry (Eur J Med Chem) Vol. 43 Issue 11 Pg. 2373-9 (Nov 2008) ISSN: 0223-5234 [Print] France
PMID18387711 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Antigens, Viral
  • Antineoplastic Agents
  • Triterpenes
Topics
  • Animals
  • Antigens, Viral (immunology)
  • Antineoplastic Agents (chemistry, pharmacology)
  • Basidiomycota (chemistry)
  • Herpesvirus 4, Human (drug effects, immunology)
  • Magnetic Resonance Spectroscopy
  • Mice
  • Models, Molecular
  • Molecular Structure
  • Skin Neoplasms (prevention & control)
  • Triterpenes (chemistry, pharmacology)

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