Abstract | BACKGROUND: PATIENTS AND DESIGN: We evaluated 20 women with PCOS, 18 women with pGDM and 19 controls, all matched according to body mass index (BMI). Fasting blood samples were drawn in all women 3-6 days after spontaneous or dydrogesterone-induced withdrawal bleeding. Body fat distribution was assessed using dual-energy X-ray absorptiometry in all women. RESULTS: CONCLUSIONS: Certain markers of insulin resistance are increased in both women with PCOS and women with pGDM, while low-grade inflammation is increased only in PCOS. PCOS and GDM might represent specific phenotypes of one disease entity with an increased risk of cardiovascular disease, whereby women with PCOS demonstrate an augmented cardiovascular risk profile.
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Authors | Robert Thomann, Nadia Rossinelli, Ulrich Keller, Brigitte Frey Tirri, Christian De Geyter, Juan Ruiz, Marius Kränzlin, Jardena J Puder |
Journal | Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology
(Gynecol Endocrinol)
Vol. 24
Issue 4
Pg. 199-206
(Apr 2008)
ISSN: 0951-3590 [Print] England |
PMID | 18382906
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Lipids
- Sex Hormone-Binding Globulin
- Tumor Necrosis Factor-alpha
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Topics |
- Adult
- Body Fat Distribution
- Case-Control Studies
- Chronic Disease
- Diabetes, Gestational
(blood, epidemiology)
- Female
- Humans
- Inflammation
(blood, epidemiology, etiology, pathology)
- Insulin Resistance
(physiology)
- Lipids
(blood)
- Metabolic Syndrome
(epidemiology)
- Polycystic Ovary Syndrome
(blood, complications, epidemiology)
- Pregnancy
- Reproductive History
- Sex Hormone-Binding Globulin
(analysis)
- Tumor Necrosis Factor-alpha
(blood)
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