In vivo efficacy of beta-cyclodextrin derivatives against anthrax lethal toxin.

Abstract

We evaluated the in vivo efficacy of three beta-cyclodextrin derivatives that block the anthrax protective antigen pore. These compounds were at least 15-fold more potent than previously described beta-cyclodextrins in protecting against anthrax lethal toxin in a rat model. One of the drugs was shown to protect mice from bacterial infection.

• Authors: Mahtab Moayeri, Tanisha M Robinson, Stephen H Leppla, Vladimir A Karginov
• Journal: Antimicrobial agents and chemotherapy (Antimicrob Agents Chemother) Vol. 52 Issue 6 Pg. 2239-41 (Jun 2008) ISSN: 1098-6596 [Electronic] United States
• PMID: 18378717 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, N.I.H., Intramural)

Chemical References

• Antigens, Bacterial
• Bacterial Toxins
• anthrax toxin
• beta-Cyclodextrins

Topics

• Animals
• Anthrax (drug therapy, mortality, prevention & control)
• Antigens, Bacterial (metabolism)
• Bacillus anthracis (drug effects, pathogenicity)
• Bacterial Toxins (antagonists & inhibitors, metabolism)
• Disease Models, Animal
• Mice
• Treatment Outcome
• beta-Cyclodextrins (chemistry, pharmacology)