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The spectrum and treatment of angioedema.

Abstract
Angioedema manifests as episodes of localized swelling in the dermis and submucosa. The key to successful management is detection and avoidance of triggers, early recognition of attacks, and aggressive airway management when warranted. Review of a patient's medication list may identify drugs that include angiotensin-converting enzyme inhibitor or angiotensin receptor blockers as the cause. Initial treatment in a patient presenting with most forms of angioedema includes antihistamines and glucocorticoids if required. Epinephrine should be administered if there is concern for laryngeal edema. Patients who have a known history of hereditary angioedema should receive C1 esterase inhibitor concentrate or fresh-frozen plasma.
AuthorsViviana M Temiño, R Stokes Peebles Jr
JournalThe American journal of medicine (Am J Med) Vol. 121 Issue 4 Pg. 282-6 (Apr 2008) ISSN: 1555-7162 [Electronic] United States
PMID18374684 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Review)
Chemical References
  • Histamine H1 Antagonists
Topics
  • Acute Disease
  • Airway Obstruction (prevention & control)
  • Angioedema (epidemiology, immunology, therapy)
  • Angioedemas, Hereditary (epidemiology, immunology, therapy)
  • Combined Modality Therapy
  • Female
  • Histamine H1 Antagonists (therapeutic use)
  • Humans
  • Incidence
  • Laryngeal Edema (epidemiology, immunology, therapy)
  • Male
  • Prognosis
  • Recurrence
  • Risk Assessment
  • Severity of Illness Index
  • Treatment Outcome

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