Recognition of DNA double strand breaks by the BRCA1 tumor suppressor network.

Abstract

DNA double-strand breaks (DSBs) occur in response to both endogenous and exogenous genotoxic stress. Inappropriate repair of DSBs can lead to either loss of viability or to chromosomal alterations that increase the likelihood of cancer development. In strong support of this assertion, many cancer predisposition syndromes stem from germline mutations in genes involved in DNA DSB repair. Among the most prominent of such tumor suppressor genes are the Breast Cancer 1 and Breast Cancer 2 genes (BRCA1 and BRCA2), which are mutated in familial forms of breast and ovarian cancer. Recent findings implicate BRCA1 as a central component of several distinct macromolecular protein complexes, each dedicated to distinct elements of DNA DSB repair and tumor suppression. Emerging evidence has shed light on some of the molecular recognition processes that are responsible for targeting BRCA1 and its associated partners to DNA and chromatin directly flanking DSBs. These events are required for BRCA1-dependent DNA repair and tumor suppression. Thus, a detailed temporal and spatial knowledge of how breaks are recognized and repaired has profound implications for understanding processes related to the genesis of malignancy and to its treatment.

• Authors: Roger A Greenberg
• Journal: Chromosoma (Chromosoma) Vol. 117 Issue 4 Pg. 305-17 (Aug 2008) ISSN: 0009-5915 [Print] Austria
• PMID: 18369654 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Review)

Chemical References

• Multiprotein Complexes

Topics

• DNA Breaks, Double-Stranded
• DNA Repair
• Genes, BRCA1
• Humans
• Models, Genetic
• Multiprotein Complexes (genetics)
• Mutation (genetics)
• Neoplasms (genetics, metabolism)
• Signal Transduction (genetics)