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Safety and technical success of methylene blue dye for lymphatic mapping in breast cancer.

AbstractBACKGROUND:
We aimed to evaluate the safety and efficacy of methylene blue dye (MBD) for sentinel lymph node (SLN) mapping in breast cancer.
METHODS:
A total of 398 patients undergoing 401 SLN biopsy procedures with MBD were retrospectively reviewed and divided into 3 groups based on dye concentration and location of dye injection. Technical success and complication rates were compared.
RESULTS:
Overall technical success of SLN biopsy was 99.7%. Technical success of SLN mapping with MBD was lowest in the group receiving full strength dye in a peritumoral location (74%) and highest in the group that received very dilute MBD (1.25 mg/mL) in the subareolar location (92%, P = .004). The complication rate was highest in the first group (21%) and lowest in the latter (2%, P = .0003).
CONCLUSIONS:
Dilute MBD (1.25 mg/mL) successfully maps SLNs with very few complications.
AuthorsShaheen Zakaria, Tanya L Hoskin, Amy C Degnim
JournalAmerican journal of surgery (Am J Surg) Vol. 196 Issue 2 Pg. 228-33 (Aug 2008) ISSN: 1879-1883 [Electronic] United States
PMID18367146 (Publication Type: Journal Article)
Chemical References
  • Indicators and Reagents
  • Methylene Blue
Topics
  • Adult
  • Aged
  • Aged, 80 and over
  • Breast Neoplasms (pathology)
  • Female
  • Follow-Up Studies
  • Humans
  • Indicators and Reagents
  • Lymph Nodes (pathology)
  • Lymphatic Metastasis
  • Methylene Blue (adverse effects)
  • Middle Aged
  • Retrospective Studies
  • Sentinel Lymph Node Biopsy (methods)

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