Treatment for chronic prostatitis/chronic pelvic pain syndrome: levofloxacin, doxazosin and their combination.

Abstract

INTRODUCTION:

We performed a prospective, randomized study to examine the efficacies of levofloxacin and doxazosin alone and as a combination therapy in patients with National Institutes of Health (NIH) category III chronic prostatitis/chronic pelvic pain syndrome.

PATIENTS AND METHODS:

Men with a NIH diagnosis of category III chronic prostatitis/chronic pelvic pain syndrome and who had experienced pelvic pain for more than 3 months during the last 6 months were enrolled. All patients underwent treatment for 6 weeks. The patients were assessed at baseline and after 2 and 6 weeks by using the NIH Chronic Prostatitis Symptom Index. Eighty-one men (average age 40.1 years) were randomized to either the levofloxacin group (n = 26), the doxazosin group (n = 26), or the combination group (n = 29).

RESULTS:

The average baseline NIH Chronic Prostatitis Symptom Index total scores were 22.6, 22.4, and 24.1, respectively. At 6 weeks, the total scores were 11.2 (response rate 50.3%), 17.7 (response rate 21.1%), and 13.1 (response rate 45.6%), respectively. The levofloxacin group showed a higher response rate than the doxazosin group, not at 2 weeks but at 6 weeks (p < 0.001).

CONCLUSIONS:

For a 6-week short-term treatment levofloxacin is more effective than doxazosin for chronic prostatitis/chronic pelvic pain syndrome. In addition, levofloxacin monotherapy was also more effective when compared with the combination therapy.

• Authors: Chang Wook Jeong, Dae Jung Lim, Hwancheol Son, Sang Eun Lee, Hyeon Jeong
• Journal: Urologia internationalis (Urol Int) Vol. 80 Issue 2 Pg. 157-61 ( 2008) ISSN: 1423-0399 [Electronic] Switzerland
• PMID: 18362485 (Publication Type: Journal Article, Randomized Controlled Trial)

Chemical References

• Adrenergic alpha-Antagonists
• Anti-Bacterial Agents
• Levofloxacin
• Ofloxacin
• Doxazosin

Topics

• Adrenergic alpha-Antagonists (therapeutic use)
• Adult
• Anti-Bacterial Agents (therapeutic use)
• Doxazosin (therapeutic use)
• Drug Therapy, Combination
• Humans
• Levofloxacin
• Male
• Middle Aged
• Ofloxacin (therapeutic use)
• Prospective Studies
• Prostatitis (drug therapy)