Abstract | BACKGROUND AND PURPOSE: METHODS: RESULTS:
Lp-PLA(2) expression was significantly higher in plaques of symptomatic patients than asymptomatic patients (1.66+/-0.19 versus 1.14+/-0.10, P<0.05) and localized mainly to shoulder and necrotic lipid core areas in colocalization with oxLDL and macrophage content. Similarly, Lp-PLA(2) expression was related to collagen content, which was lower in plaques from symptomatic patients than in plaques from asymptomatic patients (9.1+/-2.2 versus 18.5+/-1.7% of staining/field, P<0.001). LysoPC plaque concentration was significantly higher in plaques of symptomatic than asymptomatic patients (437.0+/-57.91 versus 228.84+/-37.00 mmol/L, P<0.05). CONCLUSIONS:
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Authors | Dallit Mannheim, Joerg Herrmann, Daniele Versari, Mario Gössl, Fredric B Meyer, Joseph P McConnell, Lilach O Lerman, Amir Lerman |
Journal | Stroke
(Stroke)
Vol. 39
Issue 5
Pg. 1448-55
(May 2008)
ISSN: 1524-4628 [Electronic] United States |
PMID | 18356547
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Chemical References |
- Biomarkers
- Lipoproteins, LDL
- Lysophosphatidylcholines
- Collagen
- 1-Alkyl-2-acetylglycerophosphocholine Esterase
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Topics |
- 1-Alkyl-2-acetylglycerophosphocholine Esterase
(analysis, metabolism)
- Aged
- Biomarkers
(analysis, metabolism)
- Carotid Arteries
(metabolism, pathology, physiopathology)
- Carotid Artery Diseases
(metabolism, physiopathology, surgery)
- Collagen
(metabolism)
- Endarterectomy, Carotid
- Female
- Humans
- Immunoblotting
- Immunohistochemistry
- Inflammation
(metabolism, pathology, physiopathology)
- Lipoproteins, LDL
(metabolism)
- Lysophosphatidylcholines
(analysis, metabolism)
- Macrophages
(metabolism)
- Male
- Oxidative Stress
- Predictive Value of Tests
- Up-Regulation
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