Clinical experience with DTPw-HBV and DTPw-HBV/Hib combination vaccines.

Abstract

BACKGROUND:

Combined diphtheria-tetanus-whole-cell pertussis (DTPw) vaccines remain the cornerstone of many childhood vaccination programs. Larger DTPw-based combination vaccines facilitate high coverage and protection against other childhood pathogens, such as hepatitis B (HBV) and Haemophilus influenzae type b (Hib). Such vaccines have been available since the mid-1990s (Tritanrix-HBV and Tritanrix-HBV/Hib; GlaxoSmithKline [GSK] Biologicals), demonstrating excellent immunogenicity in various schedules. In order to address growing demand for DTPw-based vaccines, GSK Biologicals have developed the Zilbrix range using a new DTPw antigen source and containing reduced quantities of polyribosylribitol phosphate [PRP].

OBJECTIVE:

This article presents clinical trial results for both DTPw-based vaccines.

METHODS:

GSK Biologicals provided a comprehensive data package, which was supplemented with a Medline literature search.

CONCLUSION:

New antigen sources and reduced PRP will ensure the continued supply of DTPw-based combination vaccines for vital global mass vaccination campaigns.

• Authors: Roman Prymula, Stanislav Plisek
• Journal: Expert opinion on biological therapy (Expert Opin Biol Ther) Vol. 8 Issue 4 Pg. 503-13 (Apr 2008) ISSN: 1744-7682 [Electronic] England
• PMID: 18352853 (Publication Type: Journal Article, Review)

Chemical References

• Antibodies, Bacterial
• Antigens, Bacterial
• Diphtheria-Tetanus-Pertussis Vaccine
• Haemophilus Vaccines
• Haemophilus influenzae type b polysaccharide vaccine
• Hepatitis B Antibodies
• Hepatitis B Antigens
• Hepatitis B Vaccines
• Polysaccharides
• Polysaccharides, Bacterial
• Tritanrix-HepB vaccine
• Vaccines, Combined
• polyribitol phosphate

Topics

• Antibodies, Bacterial (blood)
• Antigens, Bacterial (immunology)
• Bacterial Capsules
• Child
• Child, Preschool
• Clinical Trials as Topic
• Diphtheria-Tetanus-Pertussis Vaccine (administration & dosage, adverse effects, immunology)
• Global Health
• Haemophilus Vaccines (administration & dosage, adverse effects, immunology)
• Hepatitis B Antibodies (blood)
• Hepatitis B Antigens (immunology)
• Hepatitis B Vaccines (administration & dosage, adverse effects, immunology)
• Humans
• Immunization Schedule
• Immunization, Secondary
• Infant
• Infant, Newborn
• Mass Vaccination
• Polysaccharides (immunology)
• Polysaccharides, Bacterial (administration & dosage, adverse effects, immunology)
• Treatment Outcome
• Vaccines, Combined (administration & dosage, adverse effects, immunology)