Cellular studies of MrDb (DDX18).

Abstract

Helicases are present in viruses, prokaryotes, and eukaryotes, and several of them have been linked to human diseases. Here we study the role of one putative DEAD-box RNA helicase, MrDb (DDX18), in tumor cells. We show that MrDb is a nucleolar protein ubiquitously expressed in tumor cells and that it is more abundantly expressed in proliferating cells. Inhibition of MrDb with dominant negative mutant or a shRNA reduces tumor cell proliferation without inducing a cell cycle arrest or apoptosis. These findings suggest that MrDb is important for cell proliferation and that its inhibition could prevent tumor cell proliferation.

• Authors: Sandy Dubaele, Patrick Chène
• Journal: Oncology research (Oncol Res) Vol. 16 Issue 12 Pg. 549-56 ( 2007) ISSN: 0965-0407 [Print] United States
• PMID: 18351129 (Publication Type: Journal Article)

Chemical References

• RNA
• DDX18 protein, human
• DEAD-box RNA Helicases

Topics

• Apoptosis (physiology)
• Cell Cycle (physiology)
• Cell Line, Tumor
• Cell Proliferation
• DEAD-box RNA Helicases (metabolism)
• Drug Delivery Systems
• Gene Expression (physiology)
• Humans
• Mutation
• RNA (metabolism)